ENGLISH

Individualized Drug Therapy for Patients. Basic Foundations, Relevant Software and Clinical Applications

By Roger W. Jelliffe and Michael Neely (Eds.)

Book information

Publisher
Academic Press
Year
2016
ISBN
9780128033494, 9780128033487
Language
english
Format
PDF
Filesize
29 MB (30579827 bytes)
Edition
1st Edition
Pages
434 \408
Time added
2017-08-08 21:00:00
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Description

Individualized Drug Therapy for Patients: Basic Foundations, Relevant Software and Clinical Applications focuses on quantitative approaches that maximize the precision with which dosage regimens of potentially toxic drugs can hit a desired therapeutic goal. This book highlights the best methods that enable individualized drug therapy and provides specific examples on how to incorporate these approaches using software that has been developed for this purpose. The book discusses where individualized therapy is currently and offers insights to the future. Edited by Roger Jelliffe, MD and Michael Neely, MD,renowned authorities in individualized drug therapy, and with chapters written by international experts, this book provides clinical pharmacologists, pharmacists, and physicians with a valuable and practical resource that takes drug therapy away from a memorized ritual to a thoughtful quantitative process aimed at optimizing therapy for each individual patient. Content: Front-matter,Copyright,Dedication,List of Contributors,Preface,Acknowledgments,Introduction: Don’t Just Dose—Choose a Specific Target Goal, Suited to the Patient’s Need, and Dose to Hit it Most PreciselyEntitled to full textSection I: Basic Techniques for Individualized TherapyChapter 1 - Basic Pharmacokinetics and Dynamics for Clinicians, Pages 3-18, R. Jelliffe, M. Neely Chapter 2 - Describing Drug Behavior in Groups of Patients, Pages 19-25, R. Jelliffe Chapter 3 - Developing Maximally Precise Dosage Regimens for Patients—Multiple Model (MM) Dosage Design, Pages 27-31, R. Jelliffe Chapter 4 - Optimizing Laboratory Assay Methods for Individualized Therapy, Pages 33-46, R. Jelliffe Chapter 5 - Evaluation of Renal Function, Pages 47-56, R. Jelliffe Chapter 6 - Using the BestDose Clinical Software—Examples With Aminoglycosides, Pages 59-75, R. Jelliffe Chapter 7 - Monitoring the Patient: Four Different Bayesian Methods to Make Individual Patient Drug Models, Pages 77-90, R. Jelliffe, A. Schumitzky, D. Bayard, M. Neely Chapter 8 - Monitoring Each Patient Optimally: When to Obtain the Best Samples for Therapeutic Drug Monitoring, Pages 91-102, R. Jelliffe, D. Bayard, M. Neely Chapter 9 - Optimizing Individualized Drug Therapy in the ICU, Pages 103-114, R. Jelliffe Chapter 10 - Quantitative Modeling of Diffusion Into Endocardial Vegetations, the Postantibiotic Effect, and Bacterial Growth and Kill, Pages 115-134, R. Jelliffe Chapter 11 - Individualizing Digoxin Therapy, Pages 135-154, R. Jelliffe Chapter 12 - Optimizing Single-Drug Antibacterial and Antifungal Therapy, Pages 157-179, M. Neely, R. Jelliffe Chapter 13 - Combination Chemotherapy With Anti-Infective Agents, Pages 181-206, G.L. Drusano Chapter 14 - Controlling Antiretroviral Therapy in Children and Adolescents with HIV Infection, Pages 207-238, M. Neely, N.Y. Rakhmanina Chapter 15 - Individualizing Tuberculosis Therapy, Pages 239-254, S. Goutelle, P. Maire Chapter 16 - Individualizing Transplant Therapy, Pages 255-279, P. Marquet, A. Åsberg Chapter 17 - Individualizing Dosage Regimens of Antineoplastic Agents, Pages 281-306, A. Aldaz, P. Schaiquevich Chapter 18 - Controlling Busulfan Therapy in Children, Pages 307-326, M. Neely, M. Philippe, N. Bleyzac, S. Goutelle Chapter 19 - Individualizing Antiepileptic Therapy for Patients, Pages 327-371, I. Bondareva Chapter 20 - Individualizing Drug Therapy in the Elderly, Pages 373-382, P. Maire, L. Bourguignon, S. Goutelle, M. Ducher, R. Jelliffe Chapter 21 - The Present and Future State of Individualized Therapy, Pages 383-392, R. Jelliffe, M. Neely Index, Pages 393-399

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