Virus Infection and Tumorigenesis: Hints from Marine Hosts’ Stress Responses

Description

This book reviews the latest research on the molecules and mechanisms of marine host stress responses to viral infections and tumorigenesis. It offers an overview of the state of the art in the field as well as future directions. Metabolism disorder is a characteristic of tumorigenesis. Since viruses complete their life cycle in host cells, such infections cause metabolic disorders in the host. As such, the mechanisms of virus pathogenesis and tumor progression are similar or even identical. In essence, the role of antiviral molecules is to maintain the metabolic homeostasis of infected host cells, and the antiviral molecules induced by virus infection may play an important role in antitumor pathways, resulting in cancer cell death or restoring the disordered metabolism of cancer cells. The molecules generated during host stress responses to viruses can also contribute to the antitumor mechanisms in humans. However, the relationship between host stress responses to virus infection and tumorigenesis has not been extensively explored. In recent years, studies have shown that marine host stress responses to viral invasion can be good models for exploring human antitumor mechanisms. Stimulating further research in the field, this book offers graduate students and researchers with comprehensive insights into host stress responses to viral invasion and tumor progression. It is also a valuable resource for those working in the pharmaceutical industry interested in drug discovery based on molecules derived from host stress responses to viral infection. Front Matter ....Pages i-v Overview of Virus Infection and Tumorigenesis (Geng Yang, Xiaobo Zhang)....Pages 1-23 Marine Viruses (Tianliang He, Min Jin, Xiaobo Zhang)....Pages 25-62 Marine Invertebrate Stress Responses to Virus Infection (Yaodong He, Yi Gong, Xiaobo Zhang)....Pages 63-104 The Roles of MicroRNAs in Antiviral Immunity of Marine Invertebrates (Yalei Cui, Le Shu, Xiaobo Zhang)....Pages 105-140 Marine Microbe Stress Responses to Bacteriophage Infection (Min Jin, Tianliang He, Xiaobo Zhang)....Pages 141-174 Roles of Microbial Metabolites in Bacteriophage-Microbe Interactions (Chenxi Xu, Min Jin, Xiaobo Zhang)....Pages 175-207 Tumorigenesis and Metabolism Disorder (Fan Yang, Le Shu, Xiaobo Zhang)....Pages 209-250 Effects of MicroRNAs from Marine Invertebrate Stress Responses to Virus Infection on Tumorigenesis (Yi Gong, Yalei Cui, Xiaobo Zhang)....Pages 251-283 Antitumor Activities of Secondary Metabolites from Marine Microbe Stress Responses to Virus Infection (Tianliang He, Chenxi Xu, Xiaobo Zhang)....Pages 285-318