Perinatal Neuropathology
Book information
Description
There is an increasing demand for high-standard fetal and infant neuropathology examinations. Novel imaging techniques, development of new diagnostic methods and advances in genetics have stimulated the interest in gaining additional knowledge on developmental, perinatal and neonatal neuropathology. Approaching the subject from a practical standpoint, diagnostic templates for reports are provided in this essential guide to aid clinicians with different areas of expertise. Each chapter will includes numerous high-quality images, accompanied by explanatory legends from the authors' own experiences. Covering autopsy and tissue processing techniques, the authors discuss a range of disorders such as neural tube defects, brain tumours, storage disorders and many others. This book provides access to an online version on Cambridge Core, which can be accessed via the code printed on the inside of the cover. Compiling the latest advances in fetal and infant diagnostics and care, this book is a highly valuable educational resource. Cover Half-title page Title page Copyright page Contents Preface Acknowledgments List of Abbreviations Section I Techniques and Practical Considerations Approach to Autopsy of the Perinatal Nervous System Chapter 1 Clinical Considerations Chapter 2 Imaging Chapter 3 External Exam of the Fetus/Infant Chapter 4 Autopsy and Research Consent section Ancillary Studies Chapter 5 Microbiology Chapter 6 Cytogenetics Chapter 7 Metabolic Studies Chapter 8 Toxicology section Prosection Techniques Chapter 9 Brain Prosection Chapter 10 Spinal Cord Prosection Chapter 11 Neuromuscular Specimens Chapter 12 Eye Specimens section Tissue Selection Chapter 13 Selection of Brain Areas for Microscopic Examination Chapter 14 Technical Considerations in Perinatal CNS Tissue Processing Chapter 15 Staining Techniques section Reporting Chapter 16 Formulation of Diagnosis Chapter 17 Reporting Templates Chapter 18 Medicolegal Considerations Section 2 Human Nervous System Development Neuroanatomic Site Development Chapter 19 Human Nervous System Development: Embryonic and Early Fetal Events Chapter 20 Cerebral Cortex, Including Germinal Matrix Chapter 21 White Matter, Including Myelination Chapter 22 Cerebellum: Development of the Rhombic Lip, Cerebellar Cortex, Dentate Nucleus Chapter 23 Spinal Cord Chapter 24 Skeletal Muscle and Peripheral Nerve Chapter 25 Fetal and Infant Eye section Growth Parameters Chapter 26 Head Size and Brain Weight Section 3 Stillbirth Autolysis, Artifacts, and Stillbirths Chapter 27 Autolysis and Artifacts section Stillbirths Chapter 28 Neuropathology of Stillbirth Section 4 Disruptions / Hypoxic-Ischemic Injury Cellular Responses Chapter 29 Neuronal Death Chapter 30 Macroglial Reactions Chapter 31 Inflammatory Responses section Gray Matter Chapter 32 Supratentorial Gray Matter Damage and Disruptions Chapter 33 Brainstem and Spinal Cord Disruptions section White Matter Chapter 34 Periventricular Leukomalacia and Diffuse White Matter Injury section Germinal Matrix Chapter 35 Periventricular and Intraventricular Brain Hemorrhage section Cerebellum Chapter 36 Cerebellar Lesions Section 5 Malformations Neural Tube Defects and Patterning Defects Chapter 37 Defects of Neural Tube Closure and Axial Mesodermal Defects Chapter 38 Disorders of Early Midline Patterning Section Hydrocephalus Chapter 39 Fetal and Perinatal Hydrocephalus section Neuronal Migration Disorders Chapter 40 Cerebral Cortical Migration Disorders section Genetic Syndromes and Phakomatoses Chapter 41 Fragile X Syndrome Chapter 42 Down Syndrome - Trisomy 21 Chapter 43 Edwards Syndrome - Trisomy 18 Chapter 44 Patau Syndrome - Trisomy 13 Chapter 45 Tuberous Sclerosis Complex Chapter 46 Sturge-Weber Syndrome Chapter 47 Neurocutaneous Melanosis Section 6 Perinatal Neurooncology Chapter 48 Congenital and Perinatal Brain Tumors Section 7 Spinal and Neuromuscular Disorders Arthrogryposis Chapter 49 Arthrogryposis Multiplex Congenita Section Spinal Muscular Atrophy Chapter 50 Spinal Muscular Atrophy (SMA) Section Early-Onset Hereditary Neuropathies Chapter 51 Charcot-Marie-Tooth (CMT) Neuropathies Section Congenital Muscle Disorders Chapter 52 Congenital Myasthenic Syndromes Chapter 53 Congenital Muscular Dystrophies Chapter 54 Congenital Myopathies Chapter 55 Other Congenital Muscle Disorders Section 8 Eye Disorders Chapter 56 Congenital Eye Malformations and Deformations Section 9 Infections In Utero Infections Chapter 57 Congenital Viral, Bacterial, and Parasitic Infections Section Peri- and Postnatal Infections Chapter 58 Meningitis and Encephalitis Section 10 Metabolic / Toxic Disorders: Storage Diseases Storage Diseases Chapter 59 Lysosomal Disorders Chapter 60 Peroxisomal Disorders Section Kernicterus Chapter 61 Clinicopathological Features of Kernicterus Section Mitochondrial Diseases Chapter 62 Clinicopathological Features of Mitochondrial Diseases Section Maternal Toxin Exposure Chapter 63 Ethanol and Other Agents Section 11 Forensic Neuropathology Trauma Chapter 64 Birth Trauma Chapter 65 Accidental and Nonaccidental Death Section Sudden Unexpected Death Chapter 66 Sudden Unexpected Death in Infancy and Childhood Appendix 1 Technical Considerations in Perinatal CNS Index
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