ENGLISH

Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis

By Renato Alberto Sinico , Loïc Guillevin

Book information

Publisher
Springer International Publishing
Year
2020
ISBN
978-3-030-02238-9, 978-3-030-02239-6
Language
english
Format
PDF
Filesize
9 MB (8995078 bytes)
Series
Rare Diseases of the Immune System
Edition
1st ed. 2020
Pages
X, 336\334
Time added
2020-02-08 04:40:59
Medicine & Public Health; Rheumatology; Nephrology

Description

This volume, written by well-known experts in the field, covers all aspects of Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis (AAV). The expression refers to a group of diseases, characterized by destruction and inflammation of small vessels. The clinical signs vary and affect several organs, such as the kidney, lung, skin, nervous system and others. The opening chapters give some historical hints, explain the genetic basis of the disease and provide insights into the pathogenesis derived from recent experimental studies and guides the reader through classification and nomenclature. A large part of the book is then devoted to a detailed description of the specific related diseases and their clinical presentations, the disease course, and potential complications. The advice regarding treatment is based on the best currently available evidence in this constantly evolving area. The book is part of Springer’s series Rare Diseases of the Immune System, which presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. AAVs are systemic autoimmune diseases of unknown cause that affect small (to medium) sized blood vessels. They include granulomatosis with polyangiitis (formerly Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (formerly Churg–Strauss syndrome). This volume will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with these diseases. Front Matter ....Pages i-x Front Matter ....Pages 1-1 Introduction: Nomenclature and Classification (J. Charles Jennette, Ronald J. Falk)....Pages 3-17 Genetics of ANCA-Associated Vasculitis (Federico Alberici, Paul Anthony Lyons, Davide Martorana)....Pages 19-32 Etiopathogenesis of ANCA-Associated Vasculitis (Delphine Sterlin, Alexis Mathian, Makoto Miyara)....Pages 33-45 ANCA: Methods and Clinical Significance (Elena Csernok, Antonella Radice)....Pages 47-56 Activity and Damage (Raashid A. Luqmani)....Pages 57-76 Eosinophilic Granulomatosis with Polyangiitis (EGPA, Churg–Strauss) (Yann Nguyen, Loïc Guillevin)....Pages 77-95 Granulomatosis with Polyangiitis (Christian Pagnoux)....Pages 97-129 Microscopic Polyangiitis (Renato Alberto Sinico, Filippo Maria Sala, Maria Rosa Pozzi, Paolo Fabbrini, Federico Pieruzzi)....Pages 131-144 Front Matter ....Pages 145-145 ANCA-Associated Vasculitis—ENT Involvement (Trimarchi Matteo, Galli Andrea, Roberto Teggi)....Pages 147-161 Lung Involvement in ANCA-Associated Vasculitis (Marta Casal Moura, Ulrich Specks)....Pages 163-176 Kidney Involvement (Renato Alberto Sinico, Fabio Pagni, Vincenzo L’Imperio, Valentina Binda, Paolo Fabbrini, Federico Pieruzzi et al.)....Pages 177-192 Peripheral Nervous System Involvement (Michael P. Collins, P. James B. Dyck)....Pages 193-237 Central Nervous System Involvement in ANCA-Associated Vasculitis (Hubert de Boysson)....Pages 239-249 Skin Involvement (Angelo Valerio Marzano, Simona Tavecchio, Emilio Berti)....Pages 251-267 Miscellaneous Organ Involvement in ANCA-Associated Vasculitis (Giorgio Trivioli, Augusto Vaglio)....Pages 269-292 Prognosis and Outcomes of ANCA-Associated Vasculitis (David Jayne)....Pages 293-311 Treatment of ANCA-Associated Vasculitides (Loïc Guillevin, Loïc Raffray, Yann Nguyen, Benjamin Chaigne, Benjamin Terrier)....Pages 313-328 Back Matter ....Pages 329-336

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