Lymph Node Metastasis in Gastrointestinal Cancer
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Description
This book provides the most comprehensive and up-to-date knowledge of lymph node micrometastasis (LMM) and sentinel node navigation surgery (SNNS) in gastrointestinal cancers. Lymph node metastasis is a critically important prognostic factor in gastrointestinal tract cancers such as tumors of the esophagus, stomach, and colorectum. An understanding of the basic aspects of lymphatics and lymph nodes, including anatomy, histology, physiology, immunology, and molecular biology, is fundamental for physicians who are involved in cancer treatment. Furthermore, owing to the development of molecular and biological methodology, the precise recognition of LMM and its clinical significance have been clarified recently. At the same time, SNNS has actually been anticipated in treatment of breast tumors, and it is now being introduced in gastrointestinal tract cancer. For the application of SNNS, the detection of lymph node metastasis including LMM is extremely significant, because the presence of LMM determines the direction for surgery and chemo and/or radiation therapy. With these considerations in mind, the expert contributors to this book review basic and clinical approaches for LMM and SNNS including methodology for gastrointestinal cancers. Thus this volume benefits not only surgeons who treat gastrointestinal cancers but also clinical oncologists and medical scientists such as physiologists and pathologists. Front Matter ....Pages i-viii Physiology of the Gastrointestinal Lymphatics (Toshio Ohhashi, Yoshiko Kawai)....Pages 1-16 Anatomy of Lymphatics (Tatsuo Sato)....Pages 17-67 Molecular Mechanisms of Lymph Node Metastasis (Naohide Oue, Yasuhiko Kitadai, Wataru Yasui)....Pages 69-92 Front Matter ....Pages 93-93 Immunology of a Lymph Node (Ryota Hokari, Soichiro Miura)....Pages 95-110 Lymphoid Tissues Associated with Gastrointestinal (GI) Mucosa (Takahiro Nagatake, Jun Kunisawa, Hiroshi Kiyono)....Pages 111-126 Nonclinical Imaging Studies for the Diagnosis of Lymph Node Metastases (Kazunobu Ohnuki, Hirofumi Fujii)....Pages 127-157 In Vivo Imaging of Lymphatic Vessels and Lymph Nodes (Takeshi Imamura, Takashi Saitou, Sota Takanezawa, Ryosuke Kawakami)....Pages 159-176 Front Matter ....Pages 177-177 Basic Aspect: Methodology (Shuhei Ito, Takaaki Masuda, Yosuke Kuroda, Hidetoshi Eguchi, Koshi Mimori)....Pages 179-193 Clinical Aspect: Esophageal Cancer (Itaru Omoto, Yasuto Uchikado, Ken Sasaki, Takaaki Arigami, Shoji Natsugoe)....Pages 195-207 Clinical Aspect: Gastric Cancer (Takaaki Arigami, Yoshikazu Uenosono, Shigehiro Yanagita, Sumiya Ishigami, Shoji Natsugoe)....Pages 209-223 Clinical Aspects: Colorectal Cancer (Hirofumi Yamamoto, Masaki Mori)....Pages 225-236 Clinical Aspect: Chemo- and/or Radiation Therapy and Micrometastasis (Ken Sasaki, Shoji Natsugoe)....Pages 237-248 Esophageal Cancer (Yoshiaki Kajiyama, Natsumi Tomita, Takashi Hashimoto)....Pages 249-263 Front Matter ....Pages 265-265 Gastric Cancer (Koshi Kumagai, Takeshi Sano)....Pages 267-282 Colorectal Cancer (Kazushige Kawai, Kensuke Otani, Manabu Kaneko, Koji Murono, Kazuhito Sasaki, Toshiaki Watanabe)....Pages 283-302 Front Matter ....Pages 303-303 Methodology: Dye and Isotope Method (Shinichi Kinami, Takeo Kosaka)....Pages 305-321 Methodology: CT Lymphography (Akira Tangoku, Takahiro Yoshida, Hiroaki Toba, Hirokazu Takechi, Masakazu Okumua, Takeshi Nishino et al.)....Pages 323-333 Clinical Aspect: Esophageal Cancer (Yoshikazu Uenosono, Takaaki Arigami, Shigehiro Yanagita, Itaru Omoto, Ken Sasaki, Yasuto Uchikado et al.)....Pages 335-346 Clinical Aspect: Gastric Cancer (Hiroya Takeuchi, Yuko Kitagawa)....Pages 347-358
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