ENGLISH

Pharmacokinetic Challenges in Drug Discovery

By J. Dixon , A. M. Davis , C. J. Logan (auth.) , O. Pelkonen , A. Baumann , A. Reichel (eds.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
2002
ISBN
978-3-662-04385-1, 978-3-662-04383-7
DOI
10.1007/978-3-662-04383-7
Language
english
Format
PDF
Filesize
5 MB (5702604 bytes)
Series
Ernst Schering Research Foundation Workshop 37
Edition
1
Pages
306\313
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00
generalPharmacology/Toxicology; Biochemistry

Description

Despite increased spending on research and development, the number of new medicines marketed successfully continues to decline. The Pharmaceutical industry is therefore focussing on ways to reduce attrition by addressing frequent reasons for clinical drug failures very early in the drug discovery process. One of the biggest challenges is the pharmacokinetic (PK) optimisation of drug candidates tailored and predicted to have appropriate absorption, distribution, metabolism and excretion (ADME) characteristics in human. This book describes how traditional pbarmacokinetic approaches and methods are being re-invented' to meet specific needs dictated by the dynamics of the drug discovery process. The book gives an overview of state-of-the-art tools and their use in the decision-making process is discussed by a number of scientists from leading pharmaceutical companies.

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