Separation Processes in Biotechnology

Description

Series Introduction -- Foreword (Alan S. Michaels) -- Preface -- I Separation Processes -- 1 Selection of Operations in Separation Processes /Juan A. Asenio -- 2 Chemical, Physical, and Biochemical Concepts in Isolation and Purification of Proteins /Milton T. W. Hearn and Birger Anspach -- II Product Release and Recovery -- 3 Protein Secretion Systems in Microbial and Mammalian Cells /Donald T. Moir and Jen-I Mao -- 4 Cell Disruption by Homogenizer /Cady R. Engler -- 5 Bead Mill Disruption /Horst Schutte and Maria-Regina Kula -- 6 Enzymatic Cell Lysis for Product Release /Juan A. Asen;o and Barbara A. Andrews -- 7 Chemical Permeabilization of Cells for Intracellular Product Release /Thomas J. Naglak, David J. Hettwer, and Henry Y. Wang -- III Concentration and Separation Operations -- 8 Membrane Systems /A. G. Fane and J. M. Radovich -- 9 Ion -Exchange Processes /Charles D. Shuey -- 10 Aqueous Two-Phase Separations /Per-Jke Albertsson, Cote Johansson, and Folke T jerneld -- 11 Precipitation /Charles E. Glatz -- IV Purification Operations -- 12 Ion Exchange in Purification /Nien-Hwa Linda Wang -- 13 Process Affinity Chromatography /Yannis D. Clonis -- 14 Reversed-Phase and Hydrophobic Interaction Chromatography of Peptides and Proteins /Ziad El Rossi, Ann L. Lee, and Csaba Horvath -- 15 Analysis of Effluent Profiles in Large-Scale Liquid Chromatography /J. Hong -- 16 Electrically Driven Separation Processes: Analytical and Preparative Methods /Cornelius F. Ivory -- V Design of Separation Processes -- 17 Synthesis of Downstream Processes /George J. Prokopakis and Juan A. Asenjo -- 18 Automation in Protein Purification: The Use of Expert Systems for Control of Process Chromatography /Andrew C. Kenney -- 19 Downstream Processing Plant and Equipment /M. P. Brocklebank -- 20 Downstream Process Economics /Rajiv Datar and Carl-Gustaf Rosen -- Index.;Edited to avoid duplication and favor comprehensiveness, 20 contributors detail the recovery, separation, and purification operations of bioprocess technology. Individual chapters in this classic yet still highly relevant work emphasize concepts that are becoming more and more important when applied to the large scale versions of techniques that are considered well established. Aside from fully discussing processes, Separation Processes in Biotechnology includes sections on concentration separation and operation, purification operations, and product release and recovery. It also discusses plant operation and equipment and delves into economic considerations