ENGLISH

Heteroaromatic Lipoxin A4 Analogues: Synthesis and Biological Evaluation

By Colm Duffy (auth.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
2012
ISBN
3642246311, 9783642246319
DOI
10.1007/978-3-642-24632-6
Google Books ID
Y8-HjPZBIWwC
Language
english
Format
PDF
Filesize
5 MB (5315912 bytes)
Series
Springer Theses
Edition
1
Pages
130\150
Orientation
yes
Scanned
no
Time added
2012-03-09 12:00:00
Bioorganic Chemistry; Biochemistrygeneral; Medicinal Chemistry; Catalysis

Description

In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation.

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