ENGLISH

Statistical Mechanics and Stability of Macromolecules: Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix

By Earl Prohofsky

Book information

Publisher
Cambridge University Press
Year
1995
ISBN
0521451841, 0511524722, 052167557X, 9780511524721, 9780521451840, 9780521675574
LCC
QP624.5.S73 P76 1995
Open Library ID
OL1119682M
Language
english
Format
DJVU
Filesize
1 MB (1111376 bytes)
Pages
240\237
Topic
Physics
Time added
2011-04-11 19:55:47

Description

This book develops a statistical mechanical analysis of the stability of biological macromolecules. The author's approach is valid both for the long time-scale needed for DNA bond disruption, and also for highly cooperative transitions needed to explain helix melting. Prohofsky develops a new theoretical approach for executing macromolecule calculations. In particular the author devises a method for describing chemical bond disruption in these large systems, which is then used to determine when the helix melts and how drugs can dissociate from the helix. The author finds melting temperatures to be in excellent agreement with experimental observations.

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