Handbook of Cancer Vaccines

Description

The quest to harness the immune system for the treatment of cancer has been of great interest for more than 100 years, but new discoveries illuminating the requirements for immune activation and recognition of cancers have greatly increased the promise of reaching this goal. In Handbook of Cancer Vaccines, leading scientific investigators and clinicians distill the vast body of literature on cancer vaccines to create an authoritative survey of the scientific background for such therapeutic vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that affect all vaccines (such as immune adjuvants and prime-boost strategies), describe cutting-edge methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. Topics of particular interest include the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers, the monitoring of biologic responses to these vaccines, and the statistical and regulatory issues affecting the design and conduct of their clinical trials. Comprehensive and authoritative, the Handbook of Cancer Vaccines makes available to medical oncologists and immunologists a cutting-edge synthesis of the scientific rationale, preclinical data, and clinical results for the powerful new generation of vaccines now under development for the treatment of a wide range of human cancers. Front Matter....Pages i-xvii Front Matter....Pages 1-1 Biology of the Cancer Vaccine Immune Response....Pages 3-10 The Rational Design of T-Cell Epitopes With Enhanced Immunogenicity....Pages 11-17 Identification of Tumor Antigens Using Subtraction and Microarrays....Pages 19-29 Tumor Antigen Discovery With T Cells....Pages 31-47 Targeting Viral Antigens for the Treatment of Malignancies....Pages 49-64 Immune Defects in Cancer....Pages 65-84 Escape of Tumors From the Immune System....Pages 85-95 Front Matter....Pages 97-97 Immune Adjuvants....Pages 99-114 Heterologous Prime-Boost Vaccination in Tumor Immunotherapy....Pages 115-120 Peptide-Based Vaccines....Pages 121-135 Antibody-Inducing Cancer Vaccines Against Cell-Surface Carbohydrate Antigens....Pages 137-155 Anti-Idiotype Vaccines....Pages 157-173 Pox Viral Vaccines....Pages 175-191 Utility of Adenovirus-Based Vectors for Multiple Cancer Vaccine Approaches....Pages 193-202 Alphaviral-Based Strategies for the Immunotherapy of Cancer....Pages 203-224 DNA Vaccines....Pages 225-248 Whole-Tumor-Cell Vaccines....Pages 249-251 Gene-Modified Tumor-Cell Vaccines....Pages 253-273 Hapten-Modified Tumor Vaccines....Pages 275-296 Chaperone Proteins/Heat Shock Proteins As Anticancer Vaccines....Pages 297-316 Front Matter....Pages 97-97 Dendritic Cell Vaccines....Pages 317-329 Exosomes for Immunotherapy of Cancer....Pages 331-340 Immunocytokines for Cancer Immunotherapy....Pages 341-358 T-Cell Adoptive Immunotherapy....Pages 359-376 Front Matter....Pages 377-377 Melanoma Vaccines....Pages 379-395 Allogeneic Melanoma Lysate Vaccines....Pages 397-414 Renal Cancer Vaccines....Pages 415-423 Vaccines for Hematological Malignancies....Pages 425-449 Vaccines for the Immunotherapy of Prostate Cancer....Pages 451-464 Vaccine Therapy for Breast and Ovarian Cancers....Pages 465-489 Vaccine Therapy for Gastrointestinal Cancers....Pages 491-503 Vaccines for Lung Cancer....Pages 505-512 Vaccines for Other Tumors....Pages 513-516 Front Matter....Pages 517-517 Clinical Trial Designs for Therapeutic Vaccine Studies....Pages 519-525 Analysis of Cellular Immune Responses in Cancer Vaccine Trials....Pages 527-542 Analysis of Humoral Immune Responses in Vaccine Trials....Pages 543-561 Regulatory Issues Affecting Tumor Vaccines....Pages 563-576 Back Matter....Pages 577-592