ENGLISH

Structural and Evolutionary Genomics: Natural Selection in Genome Evolution

By Giorgio Bernardi (Eds.)

Book information

Publisher
Elsevier Science Ltd
Year
2004
ISBN
0444512551, 9780444512550
ISSN
0167-7306
Open Library ID
OL9688450M
Language
english
Format
PDF
Filesize
38 MB (40343818 bytes)
Series
New Comprehensive Biochemistry 37
Edition
1
Pages
1-434\459
Time added
2011-08-31 04:54:40

Description

Structural genomics is the study of the DNA of living organisms. Evolutionary genomics is the study of the history of the genome. These subjects are closely interlinked. They are approached in this book using as a guideline the investigations carried out in the author's laboratory, relevant literature is critically reviewed and some general conclusions are presented. The author and his collaborators have studied a vast number of genomes, ranging from prokaryotes to human, using different approaches, including physical chemistry of DNA, viral integration and molecular cytogenetics. As the subtitle indicates the book discusses the fundamental importance of natural selection in shaping genomes. In terms of numbers, neutral and nearly neutral mutations represent most mutations, but a "regional" control is exerted by natural selection (essentially negative or purifying selection). A "neo-selectionist" model is proposed for genome evolution.

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