Chemokine Receptors in Cancer

Description

Chemokine Receptors in Cancer summarizes the growing body of evidence that several chemokine receptors contribute to tumor behavior. Chemokine receptors were first identified on leukocytes and mediate directed migration of many host cells to sites of ligand expression. It is now well established that most malignant cells also express one or more chemokine receptor. This book describes our current understanding regarding how chemokine receptors contribute to tumor cell migration as well as cell survival and proliferation. The function of chemokine receptors expressed on host cells including antitumor immune effector cells as well as angiostatic and angiogeneic functions of chemokines acting on endothelial cells are described. The role of chemokine receptors that act as decoy receptors is also summarized. The therapeutic potential and challenges of targeting chemokine receptors or cognate ligands is also addressed. Front Matter....Pages i-x Chemokines and Chemokine Receptors in Cancer Progression....Pages 1-30 CXCR4 and Cancer....Pages 31-45 HIF-1 Regulation of Chemokine Receptor Expression....Pages 47-61 Chemokine Receptors Involved in Colon Cancer Progression, and Lymph Node Metastasis....Pages 63-78 The CXCR3/CXCL3 Axis in Cancer....Pages 79-91 Roles for CCR7 in Cancer Biology....Pages 93-108 The CCL5/CCR5 Axis in Cancer....Pages 109-130 CXC Chemokines in Cancer Angiogenesis....Pages 131-151 The Roles of Chemokines and Chemokine Receptors in Prostate Cancer....Pages 153-170 Back Matter....Pages 171-176