Advances in Research on Neurodegeneration

Description

Front Matter....Pages I-VIII The L -DOPA story revisited. Further surprises to be expected?....Pages 1-20 The enigma of cell death in neurodegenerative disorders....Pages 21-36 Impaired iron homeostasis in Parkinson’s disease....Pages 37-58 The molecular mechanism of dopamine-induced apoptosis: identification and characterization of genes that mediate dopamine toxicity....Pages 59-76 Glyceraldehyde-3-phosphate dehydrogenase in neurodegeneration and apoptosis signaling....Pages 77-100 Importance of familial Parkinson’s disease and parkinsonism to the understanding of nigral degeneration in sporadic Parkinson’s disease....Pages 101-116 cDNA microarray to study gene expression of dopaminergic neurodegeneration and neuroprotection in MPTP and 6-hydroxydopamine models: implications for idiopathic Parkinson’s disease....Pages 117-124 Monitoring neuroprotection and restorative therapies in Parkinson’s disease with PET....Pages 125-137 Common properties for propargylamines of enhancing superoxide dismutase and catalase activities in the dopaminergic system in the rat: implications for the life prolonging effect of (–)deprenyl....Pages 139-156 TV3326, a novel neuroprotective drug with cholinesterase and monoamine oxidase inhibitory activities for the treatment of Alzheimer’s disease....Pages 157-169 Neurotoxins induce apoptosis in dopamine neurons: protection by N-propargylamine-1(R)- and (S)-aminoindan, rasagiline and TV1022....Pages 171-186 Homocysteine and alcoholism....Pages 187-196 Neurorescuing effects of the GAPDH ligand CGP 3466B....Pages 197-214 The neuroprotective effects of CGP 3466B in the best in vivo model of Parkinson’s disease, the bilaterally MPTP-treated rhesus monkey....Pages 215-225 Neurotrophic effects of central nicotinic receptor activation....Pages 227-245 Regulation of neuronal cell death and differentiation by NGF and IAP family members....Pages 247-259 Insulin-like growth factor-1 (IGF-1): a neuroprotective trophic factor acting via the Akt kinase pathway....Pages 261-272 GDF-15/MIC-1 a novel member of the TGF-ß superfamily....Pages 273-276 Changes in cytokines and neurotrophins in Parkinson’s disease....Pages 277-290 Psychiatric complications in Parkinson’s disease....Pages 291-302 Dementia with Lewy bodies: prevalence, clinical spectrum and natural history....Pages 303-314 Neuronal degeneration and reorganization: a mutual principle in pathological and in healthy interactions of limbic and prefrontal circuits....Pages 315-333 Depression in alpha-synucleinopathies: prevalence, pathophysiology and treatment....Pages 335-343 The serotonin transporter in Alzheimer’s and Parkinson’s disease....Pages 345-350 Immunopathogenic and clinical relevance of antibodies against myelin oligodendrocyte glycoprotein (MOG) in Multiple Sclerosis....Pages 351-360 Lessons from studies of antigen-specific T cell responses in Multiple Sclerosis....Pages 361-373 Glutamate excitotoxicity — a mechanism for axonal damage and oligodendrocyte death in Multiple Sclerosis?....Pages 375-385 Evidence for enhanced neuro-inflammatory processes in neurodegenerative diseases and the action of nitrones as potential therapeutics....Pages 387-414 Back Matter....Pages 415-424