ENGLISH

DNA Repair Protocols

By Daryl S. Henderson

Book information

Publisher
Humana Press
Year
2005
ISBN
9781588295132, 1-58829-513-3
Open Library ID
OL18204188M
Language
english
Format
DJVU
Filesize
4 MB (4337340 bytes)
Series
Methods in Molecular Biology
Edition
2nd
Pages
517\517
Topic
Biology Genetics
Time added
2014-10-05 02:30:00

Description

This collection of readily reproducible techniques for repairing mammalian DNA contains fourteen entirely new chapters and many extensively revised chapters. The methods presented cover cytogenetic analysis, measuring the cellular response to ionizing radiation, detecting single-strand (nicks) and double-strand DNA breaks, detecting the presence of "adducted" bases in DNA, and preparing mismatch repair (MMR) plasmid substrates. Among the highlights are excellent coverage of both base excision repair (BER) and nucleotide excision repair (NER), useful assays for identifying and quantifying UV-induced DNA lesions and DNA breakage, gene therapy, environmental mutagenesis and cancer, and gene targeting.

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