ENGLISH

Fluoroquinolone Antibiotics

By Gerard Sheehan , Nicholas S. Y. Chew (auth.) , Allan R. Ronald , Donald E. Low (eds.)

Book information

Publisher
Birkhäuser Basel
Year
2003
ISBN
9783034894371, 9783034881036
Language
english
Format
PDF
Filesize
16 MB (16356708 bytes)
Series
Milestones in Drug Therapy
Edition
1
Pages
261\263
Time added
2020-08-30 06:11:09
Pharmacology/Toxicology; Immunology; Infectious Di

Description

The quinolones are making a significant contribution to patient care and have added a new dimension to antibacterial therapy. During the last decade, they became important agents for treating hospital-acquired infections. This volume covers their mechanisms of action, resistance mechanisms and epidemiology, pharmacokinetics, safety and clinical applications. Their effectiveness for respiratory, urinary, sexually transmitted, skin, soft tissue, bone and joint infections, infections of the eyes, ears, nose and throat, and less common infections such as mycobacterial, Brucella and others are reviewed. Also described is their use in pediatric, oncology and immunocompromised patients. The quinolone story continues to be intriguing with exciting future implications.This monograph is an important comprehensive review and update for researchers and clinicians in pharmacology, clinical medicine, molecular and cell biology, epidemiology and the pharmaceutical industry. Front Matter....Pages I-X The history of quinolones....Pages 1-10 Structure-activity relationships of quinolones....Pages 11-48 Epidemiology and mechanisms of resistance....Pages 49-71 Improved safety profile of newer fluoroquinolones....Pages 73-85 Pharmacokinetics and pharmacodynamics (PK/PD) of fluoroquinolones: tools for combating bacteria and preventing resistance....Pages 87-105 Fluoroquinolones in urinary tract infection....Pages 107-119 The quinolones and sexually transmitted infections....Pages 121-135 Gastrointestinal and intraabdominal infections....Pages 137-166 The quinolones in otitis media and upper respiratory infections....Pages 167-176 Quinolones in pneumonia....Pages 177-188 Fluoroquinolones for the treatment of respiratory tract infections other than pneumonia....Pages 189-203 Quinolones for the treatment of skin, soft tissue, bone and prosthetic joint infections....Pages 205-218 The role of fluoroquinolones in the therapy and prophylaxis of neutropenic patients with cancer....Pages 219-238 Less usual indications: Mycobacterial, Brucella, Yersinia, Francisella and other infections....Pages 239-249 The quinolones: future prospects....Pages 251-253 Back Matter....Pages 255-261

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