The Sepsis Text

Description

This textbook is written at the dawn of a new era in the management of sepsis. Recent achievements in the clinical management of septic shock are the culmination of decades of basic and applied research by innovative researchers and clinical investigators worldwide. The contributing authors to this book have spearheaded much of this research and the Editors have endeavored to create a textbook that is comprehensive in nature while maintaining a specific focus upon the multitude of work that constitutes the spectrum of sepsis research including: pathophysiology; monitoring systems; general support; microbial aspects; complications; and anti-sepsis therapies. Sepsis: The Magnitude of the Problem....Pages 1-9 Diagnosis and Source of Sepsis: The Utility of Clinical Findings....Pages 11-28 Organ Failure....Pages 29-46 Markers of Sepsis....Pages 47-66 Genetic Predisposition....Pages 67-79 Quantifying Risk in Sepsis: A Review of Illness Severity and Organ Dysfunction Scoring....Pages 81-96 The Pathogenesis of Gram-Negative Sepsis....Pages 97-115 The Pathophysiology of Gram-Positive Shock....Pages 117-134 Immunopathogenesis of Gram-Negative Shock....Pages 135-157 Involvement of Pro- and Anti-Inflammatory Cytokines in Sepsis....Pages 159-195 Pathophysiology of Immunodepression in ICU Patients....Pages 197-209 Pathophysiology of Sepsis: The Role of Nitric Oxide....Pages 211-229 Apoptosis and the Resolution of Inflammation in Sepsis....Pages 231-246 Microvascular Alterations in Sepsis....Pages 247-270 Cytopathic Hypoxia....Pages 271-284 Invasive Hemodynamic Monitoring....Pages 285-307 Value of SvO 2 in Sepsis....Pages 309-321 Blood Lactate Concentrations in Sepsis....Pages 323-338 Veno-Arterial PCO 2 Gradient....Pages 339-352 Gas Tonometry....Pages 353-373 General Hemodynamic Support....Pages 375-387 Fluid Administration....Pages 389-400 Blood Transfusion and Sepsis....Pages 401-419 Catecholamine Therapy....Pages 421-444 Regional Effects of Catecholamines....Pages 445-454 Management of Respiratory Dysfunction in Patients with Severe Sepsis....Pages 455-477 The Role of Nutritional Support in Sepsis....Pages 479-490 The Sources of Sepsis....Pages 491-503 Catheter-Related Sepsis....Pages 505-524 Control of the Source of Sepsis....Pages 525-538 Empirical Antibiotic Therapy for Patients with Severe Sepsis and Septic Shock....Pages 539-558 Candida Infections in the Intensive Care Unit....Pages 559-580 Why, When, and How to Isolate ICU Patients....Pages 581-608 The Lung in Sepsis....Pages 609-618 The Heart in Sepsis....Pages 619-631 The Brain in Sepsis....Pages 633-644 The Gut in Sepsis....Pages 645-664 The Kidney in Sepsis....Pages 665-685 The Coagulation System in Sepsis....Pages 687-704 Shoulder Fever be Treated in Sepsis?....Pages 705-717 Anti-Cytokine Therapy....Pages 719-728 Heat Shock Proteins and Sepsis: A Hot Story....Pages 729-742 Immunodepression in the Surgical Patient and Increased Susceptibility to Infection....Pages 743-756 The Place of Corticosteroids....Pages 757-768 The Place of Immunonutrition....Pages 769-785 Interference with the Coagulation System....Pages 787-800 Hemofiltration and Plasmapheresis....Pages 801-813 Endotoxin Analogs in the Treatment of Septic Shock....Pages 815-826 Vaccines Against Bacterial Endotoxins....Pages 827-836