ENGLISH

Genetic Damage in Human Spermatozoa

By Elisabetta Baldi , Monica Muratori

Book information

Publisher
Springer International Publishing
Year
2019
ISBN
978-3-030-21663-4;978-3-030-21664-1
Language
english
Format
PDF
Filesize
4 MB (4605941 bytes)
Series
Advances in Experimental Medicine and Biology 1166
Edition
2nd ed.
Pages
XIII, 210\216
Time added
2019-09-18 12:19:31
Biomedicine; Gene Expression; Gene Function; Human

Description

There are several types of damage that can be found in the male gamete. This book covers the genetic damage in spermatozoa that can originate during spermatogenesis, or during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the protocols to cryopreserve and to select spermatozoa in assisted reproduction techniques. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects. Front Matter ....Pages i-xiii Genetic Factors Affecting Sperm Chromatin Structure (Mélina Blanco, Julie Cocquet)....Pages 1-28 Age-Dependent De Novo Mutations During Spermatogenesis and Their Consequences (Francesca Cioppi, Elena Casamonti, Csilla Krausz)....Pages 29-46 The Sperm Epigenome: Implications for Assisted Reproductive Technologies (Douglas T. Carrell)....Pages 47-56 Epigenetic Transgenerational Inheritance (Joan Blanco Rodríguez, Cristina Camprubí Sánchez)....Pages 57-74 Sperm DNA Fragmentation: Mechanisms of Origin (Monica Muratori, Sara Marchiani, Lara Tamburrino, Elisabetta Baldi)....Pages 75-85 Sperm DNA Fragmentation: Consequences for Reproduction (Luke Simon, Benjamin Emery, Douglas T. Carrell)....Pages 87-105 Oxidative Damage to Sperm DNA: Attack and Defense (Joel R. Drevet, R. J. Aitken)....Pages 107-117 Interventions to Prevent Sperm DNA Damage Effects on Reproduction (Sandro C. Esteves)....Pages 119-148 Cryopreservation of Sperm: Effects on Chromatin and Strategies to Prevent Them (Donatella Paoli, Marianna Pelloni, Andrea Lenzi, Francesco Lombardo)....Pages 149-167 Effect on Sperm DNA Quality Following Sperm Selection for ART: New Insights (Nicoletta Tarozzi, Marco Nadalini, Andrea Borini)....Pages 169-187 Sperm DNA Damage in Cancer Patients (Hermance Beaud, Amelie R. Tremblay, Peter T. K. Chan, Geraldine Delbes)....Pages 189-203 Back Matter ....Pages 205-210

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