ENGLISH

Mitochondrial Dysfunction in Neurodegenerative Disorders

By Michael R. Duchen , Amy K. Reeve , Eve M. Simcox , Doug M. Turnbull (eds.)

Book information

Publisher
Springer International Publishing
Year
2016
ISBN
978-3-319-28635-8, 978-3-319-28637-2
DOI
10.1007/978-3-319-28637-2
Language
english
Format
PDF
Filesize
8 MB (7976812 bytes)
Edition
2
Pages
XI, 380\379
Time added
2016-07-20 04:00:00
Neurology; Medical Biochemistry; Neurosciences; In

Description

This second edition brings together up-to-date contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. The reader is guided through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, and on to the consequences of this dysfunction for neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets. Additional chapters have been added to the book to reflect advances in the field and there are many new contributors and topics, including how mitochondria are degraded and the interaction of the mitochondria with pathologically relevant proteins. Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.

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