ENGLISH

Gene Therapy for Neurological Disorders: Methods and Protocols

By Frederic P Manfredsson

Book information

Publisher
Humana Press
Year
2015
ISBN
1493932705, 9781493932702
DOI
10.1007/978-1-4939-3271-9
ISSN
1064-3745
LCC
2015953099
Language
english
Format
PDF
Filesize
15 MB (15316217 bytes)
Series
Methods in Molecular Biology 1382
Pages
xiv+493\509
Topic
Medicine Neurology
Orientation
yes
Paginated
yes
Scanned
portrait
Time added
2015-12-11 15:19:07
Neurosciences; Human Genetics; Neurology

Description

This volume provides a clear and detailed roadmap of how to design and execute a gene therapy experiment in order to obtain consistent results. Chapters in this book disseminate bits of unknown information that are important to consider during the course of experimentation and will answer questions such as: What delivery vehicle do you use?; How will you ensure that your vector retains stability?; What expression system best fits your needs?; What route will you choose to deliver your gene therapy agent?; How will you model the neurodegenerative disorder that you aim to investigate and what are the proven methods to treat these disorders in preclinical models? Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Gene Therapy for Neurological Disorders: Methods and Protocols, is a compilation of protocols and instructive chapters intended to give researchers, clinicians, and students of all levels, a foundation upon which future gene therapy experiments can be designed.

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