ENGLISH

Heart of the Matter: Key concepts in cardiovascular science

By Cesare Terracciano , Samuel Guymer

Book information

Publisher
Springer International Publishing
Year
2019
ISBN
978-3-030-24218-3, 978-3-030-24219-0
Language
english
Format
PDF
Filesize
8 MB (8418028 bytes)
Series
Learning Materials in Biosciences
Edition
1st ed. 2019
Pages
XV, 236\239
Time added
2020-02-08 04:41:24
Biomedicine; Molecular Medicine; Cardiovascular Bi

Description

This textbook introduces readers to the scientific basics of cardiovascular medicine and biology. It covers not only developmental but also cellular and molecular aspects of normally functioning vasculature and the heart; importantly, it also addresses the mechanisms leading to and involved in specific cardiovascular diseases. Though the main emphasis is on novel therapies and potential therapeutic targets, specific controversial topics like cardiac remodeling and regenerative capacities are also addressed. All chapters were written by lecturers from the Imperial College London, in collaboration with their students from the College’s BSc Programme in Medical Sciences with Cardiovascular Science. Bridging the gap between clinics and basic biology, the book offers a valuable guide for medical students, and for Master and PhD students in Cardiovascular Biomedicine. Front Matter ....Pages I-XV Anatomy of the Heart and Coronary Vasculature (Dominic Gyimah, Alec Saunders, Elizabeth Thong, Balvinder Handa)....Pages 1-11 Early Mechanisms of Cardiac Development (Jack Griffiths, Thomas Brand)....Pages 13-23 Later Mechanisms of Cardiac Development (Beth Taylor, Thomas Brand)....Pages 25-37 Myocardial Microstructure and Contractile Apparatus (Umamah Tarvala, Zohya Khalique)....Pages 39-48 An Introduction to the Cardiac Action Potentials (Elizabeth Thong, Ayesha Ahmed, Kenneth T. MacLeod)....Pages 49-59 Cardiac Excitation-Contraction Coupling (Fotios G. Pitoulis, Cesare M. Terracciano)....Pages 61-75 Conduction in Normal and Diseased Myocardium (Alec Saunders, Fu Siong Ng)....Pages 77-85 Cell-Based Tachyarrhythmias and Bradyarrhythmias (Rohin K. Reddy, Ben N. Cullen, Ahran D. Arnold, Zachary I. Whinnett)....Pages 87-103 The Scientific Rationale of Artificial Pacing (Dominic Gyimah, Ahran D. Arnold, Zachary I. Whinnett)....Pages 105-119 Cardiac Contractility (Fotios G. Pitoulis, Pieter P. de Tombe)....Pages 121-133 The Scientific Basis of Heart Failure (Giles Chick, Fotios G. Pitoulis, Liam Couch)....Pages 135-144 Molecular and Cellular Basis of Cardiomyopathies (Praveena Krishnakumar, Kabir Matwala, Shiv-Raj Sharma, Salomon Narodden)....Pages 145-153 Substrate Remodeling in Heart Failure (Angeliki Iakovou, Samuel Guymer, Rasheda Chowdhury)....Pages 155-166 Developments in Heart Failure: Mechanical Unloading with LVADs, Exosomes, and MicroRNAs (Samuel Guymer, Mayooran Shanmuganathan)....Pages 167-177 Pharmacological Targets of Hypertension (Haaris Rahim, Yasmin Bashir, Michael Schachter)....Pages 179-191 The Coagulation Cascade and its Therapeutic Modulation (Lieze Thielemans, Moghees Hanif, James Crawley)....Pages 193-206 Cellular and Molecular Mechanisms of Atherosclerosis (Adam Tsao, Mridul Rana, Joseph J. Boyle)....Pages 207-218 Molecular and Cellular Mechanisms of Angiogenesis (Zarius Ferozepurwalla, Jude Merzah, Lieze Thielemans, Graeme Birdsey)....Pages 219-226 Endothelial Function in Normal and Diseased Vessels (Mridul Rana, Zarius Ferozepurwalla, Justin Mason)....Pages 227-236

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