Amino Acids, Peptides and Proteins in Organic Chemistry: Analysis and Function of Amino Acids and Peptides, Volume 5

Description

This is the last of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international "who's who" in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins.The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics:Volume 1: Origins and Synthesis of Amino AcidsVolume 2: Modified Amino Acids, Organocatalysis and EnzymesVolume 3: Building Blocks, Catalysis and Coupling ChemistryVolume 4: Protection Reactions, Medicinal Chemistry, Combinatorial SynthesisVolume 5: Analysis and Function of Amino Acids and Peptides Volume 5 of this series presents a wealth of methods to analyze amino acids and peptides. Classical approaches are described, such as X-ray analysis, chromatographic methods, NMR, AFM, mass spectrometry and 2D-gel electrophoresis, as well as newer approaches, including Surface Plasmon Resonance and array technologies. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage.Further information about the 5 Volume Set and purchasing details can be viewed here.Content: Chapter 1 Mass Spectrometry of Amino Acids and Proteins (pages 1–50): Simin D. Maleknia and Richard JohnsonChapter 2 X?Ray Structure Determination of Proteins and Peptides (pages 51–95): Andrew J. FisherChapter 3 Nuclear Magnetic Resonance of Amino Acids, Peptides, and Proteins (pages 97–153): Andrea Bernini and Pierandrea TemussiChapter 4 Structure and Activity of N?Methylated Peptides (pages 155–166): Raymond S. NortonChapter 5 High?Performance Liquid Chromatography of Peptides and Proteins (pages 167–210): Reinhard I. Boysen and Milton T. W. HearnChapter 6 Local Surface Plasmon Resonance and Electrochemical Biosensing Systems for Analyzing Functional Peptides (pages 211–223): Masato Saito and Eiichi TamiyaChapter 7 Surface Plasmon Resonance Spectroscopy in the Biosciences (pages 225–247): Jing Yuan, Yinqiu Wu and Marie?Isabel AguilarChapter 8 Atomic Force Microscopy of Proteins (pages 249–276): Adam MechlerChapter 9 Solvent Interactions with Proteins and Other Macromolecules (pages 277–360): Satoshi Ohtake, Yoshiko Kita, Kouhei Tsumoto and Tsutomu ArakawaChapter 10 Role of Cysteine (pages 361–394): Lalla A. Ba, Torsten Burkholz, Thomas Schneider and Claus JacobChapter 11 Role of Disulfide Bonds in Peptide and Protein Conformation (pages 395–417): Keith K. Khoo and Raymond S. NortonChapter 12 Quantitative Mass Spectrometry?Based Proteomics (pages 419–438): Shao?En OngChapter 13 Two?Dimensional Gel Electrophoresis and Protein/Polypeptide Assignment (pages 439–462): Takashi Manabe and Ya JinChapter 14 Bioinformatics Tools for Detecting Post?Translational Modifications in Mass Spectrometry Data (pages 463–475): Patricia M. Palagi, Erik Arhne, MarKus Muller and Frederique Lisacek