ENGLISH

DNA Topoisomerases and Cancer

By Patrick Forterre (auth.) , Yves Pommier (eds.)

Book information

Publisher
Springer-Verlag New York
Year
2012
ISBN
1461403227, 9781461403227
DOI
10.1007/978-1-4614-0323-4
Google Books ID
E_7_mcEJHfYC
Language
english
Format
PDF
Filesize
5 MB (5721335 bytes)
Series
Cancer Drug Discovery and Development
Edition
1
Pages
443\456
Orientation
yes
Scanned
no
Time added
2012-02-14 18:00:00
Cancer Research; Pharmacology/Toxicology

Description

DNA topoisomerases represent an essential family of DNA processing enzymes and a large number of topoisomerase inhibitors are used clinically for the treatment of various human cancers. Novels drugs are in clinical development both against type I and type II topoisomerases. The book will include basic biochemical and structural reviews for the cancer-relevant topoisomerases. It will describe how topoisomerase dysfunctions can damage the genome and increase the risk of cancers, and the involvement of topoisomerases in programmed cell death. The book will also present the various topoisomerase inhibitors in clinical use and development and their molecular and cellular mechanisms of action.

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