ENGLISH

Carbohydrate-Based Interactions at the Molecular and the Cellular Level

Book information

Publisher
Springer International Publishing
Year
2018
ISBN
978-3-319-77705-4, 978-3-319-77706-1
Language
english
Format
PDF
Filesize
12 MB (12876629 bytes)
Series
Springer Theses
Edition
1st ed.
Pages
XXIX, 198\216
Time added
2018-08-15 07:07:45

Description

This book offers a clearly written and highly accessible account of two different aspects of carbohydrate chemistry. Carbohydrates are an essential component of life and have many important biological functions, but the details of how carbohydrates interact with other biomolecules to mediate biological signalling remain unclear. Firstly, this thesis details innovative methods to mine protein structural data to uncover new features of carbohydrate-based interactions. It also explains these findings using physical chemistry, specifically CH–pi interactions associated with the properties of the interacting partners. Carbohydrates are also critical for tissue growth and development, yet are underexploited in the materials science that underpins much of regenerative medicine. As such, the second part of this thesis describes a diverse array of techniques ranging from synthetic chemistry and enzymatic synthesis to prepare a wide variety of carbohydrates, and materials chemistry to prepare glycosylated hydrogels, to cell biology to determine the effects on cellular development for tissue engineering applications. Front Matter ....Pages i-xxix Introduction (Kieran L. Hudson)....Pages 1-34 Front Matter ....Pages 35-35 Protein–Carbohydrate Interactions in Protein X-Ray Crystal Structures (Kieran L. Hudson)....Pages 37-55 The Nature of Protein–Carbohydrate Interactions (Kieran L. Hudson)....Pages 57-86 Front Matter ....Pages 87-87 The Modifiable Scaffold for Tissue Engineering (Kieran L. Hudson)....Pages 89-101 Carbohydrate Modifiers for Tissue Engineering Scaffolds (Kieran L. Hudson)....Pages 103-128 Front Matter ....Pages 129-129 Conclusions and Future Directions (Kieran L. Hudson)....Pages 131-135 Experimental Details and Supplementary Data (Kieran L. Hudson)....Pages 137-198

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