Clinical Relevance of Genetic Factors in Pulmonary Diseases

Description

This book describes the underlying genetic basis of common pulmonary diseases and discusses their pathogenesis and pathophysiology. These insights provide the basis for understanding different subtypes and phonotypes, and will promote better treatment strategies and individualized medicine. The book provides new and valuable information for the development of the areas of study, as well as practical guidelines for clinicians engaged in treating pulmonary diseases. This volume of the Respiratory Disease Series – Diagnostic Tools and Disease Managements will broaden the understanding of beginning and experienced researchers and clinicians who treat pulmonary diseases. Moreover, residents and clinicians engaged in medical oncology will find it a valuable guide to support them in their day-to-day work. Front Matter ....Pages i-ix Front Matter ....Pages 1-1 Clinical Development of Genomic Medicine in Pulmonary Diseases: Are Genetic Factors Enough to Determine the Phenotype and Inheritance of Pulmonary Diseases? (Mari Hikichi, Shuichiro Maruoka, Shu Hashimoto)....Pages 3-14 Approaches to Understanding the Genetic Basis of Complex Diseases: Overview—What Is the Rationale for the Genome-Wide Approach to Understand Complex Diseases, Its Application and Limitations (Mayumi Tamari, Tomomitsu Hirota)....Pages 15-35 Front Matter ....Pages 37-37 Bronchial Asthma: Is Asthma Inherited? (Nobuyuki Hizawa)....Pages 39-56 COPD: Hereditary (A1-AT) and Non-hereditary—What Are the Roles of Genetic Factors in the Pathogenesis of COPD? (Nobuyuki Horita)....Pages 57-75 Smoking Behavior and Cessation (Nicotine Addiction): Are Genetic Factors Involved in Smoking Behavior? (Tetsuya Kubota, Akihito Yokoyama)....Pages 77-91 Cystic Fibrosis, Primary Ciliary Dyskinesia, and Diffuse Panbronchiolitis: Hereditary and Non-hereditary—What Are the Roles of Genetic Factors in the Pathogenesis of These Diseases? (Masaharu Shinkai)....Pages 93-106 Pulmonary Fibrosis: Hereditary and Non-hereditary—What Are the Role of Genetic Factors in the Pathogenesis of Pulmonary Fibrosis? (Takafumi Suda)....Pages 107-133 Other Diffuse Lung Diseases: Diffuse Cystic Lung Diseases (LAM, TSC, BHD), Sarcoidosis, Pulmonary Alveolar Proteinosis, and Pulmonary Alveolar Microlithiasis—What Are the Roles of Genetic Factors in the Pathogenesis of These Diseases? (Haruhiko Furusawa, Masahiro Masuo, Yoshihisa Nukui, Yasunari Miyazaki, Naohiko Inase)....Pages 135-160 Pulmonary Vascular Diseases: Pulmonary Hypertension and HHT—What Are the Roles of Genetic Factors in the Pathogenesis of Pulmonary Vascular Diseases? (Toshihiko Sugiura, Koichiro Tatsumi)....Pages 161-167 Mycobacterial Infection: TB and NTM—What Are the Roles of Genetic Factors in the Pathogenesis of Mycobacterial Infection? (Kazuko Yamamoto, Hiroshi Mukae)....Pages 169-191 Pulmonary Malignancies (1): Lung Cancer—What Are the Roles of Genetic Factors in Lung Cancer Pathogenesis? (Naozumi Hashimoto, Mitsuo Sato, Yoshinori Hasegawa)....Pages 193-206 Pulmonary Malignancies (2): Mesothelioma—What Are the Roles of Genetic Factors in the Pathogenesis of Mesothelioma? (Takashi Nakano, Eisuke Shibata, Kozo Kuribayashi, Yoshie Yoshikawa, Masaki Ohmuraya)....Pages 207-224 Genetic Factors in Sleep Disorders: What Are the Roles of Genetic Factors in the Pathogenesis of Sleep Disorders? (Kiminobu Tanizawa, Kazuo Chin)....Pages 225-254 Pharmacokinetics, Pharmacodynamics, and Toxicities: What Should We Know About Genetic Factors that Affect the Pharmacotherapy of Pulmonary Diseases? (Takashi Sato)....Pages 255-271 Front Matter ....Pages 273-273 EGFR: How Important Is EGFR Mutation Status in the Management of Lung Cancer? (Mizuki Haraguchi, Kazuhisa Takahashi)....Pages 275-293 ALK and Others: How Important Are ALK and Other Mutations in the Management of Lung Cancer? (Hisatsugu Goto, Yasuhiko Nishioka)....Pages 295-315 Front Matter ....Pages 317-317 Application of High-Throughput Technologies in Personal Genomics: How Is the Progress in Personal Genome Service? (Kaoru Mogushi, Yasuhiro Murakawa, Hideya Kawaji)....Pages 319-331 Nucleic Acid Amplification-Based Diagnostics for Pulmonary Diseases: What Is the Current State and Perspectives of Nucleic Acid Amplification Technologies Used in Diagnostics Associated with Pulmonary Diseases? (Oleg Gusev, Yoshihide Hayashizaki, Kengo Usui)....Pages 333-344