Regulation of Signal Transduction in Human Cell Research

Description

This volume focuses on the relationship between the regulation of signal transduction and disease mechanisms, and discusses how the dysregulation of intracellular signals cause diseases, cell death, carcinogenesis, and other disorders. Growth, survival, transformation, and metabolic activities at the cellular level are regulated by various intracellular signal transduction pathways. Sources that stimulate intracellular signals include intracellular stresses and signal regulators/modulators, as well as extracellular growth factors. Recent studies on signal transduction analysis using animal and human cell lines have revealed how the intracellular signals are regulated and why their dysregulation leads to pathological states such as tumorigenesis, metabolic diseases, cell death, and so on. This book highlights several important key molecules and intracellular signaling pathways such as microRNA, the TGF-beta signaling pathway, the Wnt signaling pathway and MET signaling pathway as topical and highly relevant issues in human cell research related to signal transduction. In addition to assessing the pathogenic role of these signaling pathways, it focuses on the molecular design of small molecule regulators/inhibitors of said pathways, one of the most important approaches in this area. This book offers a valuable guide, helping not only research scientists but also clinicians to understand how the dysregulation of intracellular signals leads to diseases. Front Matter ....Pages i-viii Using Genetically Engineered Mouse Models to Study Wnt Signaling in Bone Development and Disease (Zhendong A. Zhong, Nicole J. Ethen, Bart O. Williams)....Pages 1-27 Role of the Receptor-Mediated Signaling Pathways on the Proliferation and Differentiation of Pluripotent Stem Cells (Toshiaki Ishizuka)....Pages 29-41 Regulation of microRNA Expression by Growth Factors in Tumor Development and Progression (Hiroshi Itoh, Sotai Kimura, Seiji Naganuma)....Pages 43-69 Regulation of EMT by TGF-β Signaling in Cancer Cells (Masao Saitoh)....Pages 71-84 The Functional Interplay Between Pro-oncogenic RUNX2 and Hypoxia-Inducible Factor-1α (HIF-1α) During Hypoxia-Mediated Tumor Progression (Toshinori Ozaki, Mizuyo Nakamura, Takehiko Ogata, Meijie Sang, Osamu Shimozato)....Pages 85-98 DNA Damage: Cellular Responses, Repair, and Cancer Treatment (Brian M. Cartwright, Phillip R. Musich, Yue Zou)....Pages 99-127 Met Activation and Carcinogenesis (Nariyoshi Shinomiya, Qian Xie, George F. Vande Woude)....Pages 129-154 The HGF/MET Signaling and Therapeutics in Cancer (Douglas P. Thewke, Jianqun Kou, Makenzie L. Fulmer, Qian Xie)....Pages 155-181 Pericellular Activation of Peptide Growth Factors by Serine Proteases (Hiroaki Kataoka, Tsuyoshi Fukushima)....Pages 183-197 Molecular Designing of Small-Molecule Inhibitors for Apoptosis Regulation (Atsushi Yoshimori, Sei-Ichi Tanuma)....Pages 199-218