ENGLISH

Pharmacogenetics and Individualized Therapy

Book information

Year
2012
ISBN
9780470433546, 9781118116494
DOI
10.1002/9781118116494
Language
english
Format
PDF
Filesize
4 MB (4459105 bytes)
Pages
488\488
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00

Description

This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. The following section moves into specific disease areas, including cardiovascular, psychiatry, cancer, asthma/COPD, adverse drug reactions, transplantation, inflammatory bowel disease, and pain medication. Clinical practice and ethical issues make up the third section, with the fourth devoted to technologies like genotyping, genomics, and proteomics. In the fifth part, chapters discuss the impact of key regulatory issues on the pharmaceutical industry.Content: Chapter 1 Pharmacogenetics: A Historical Perspective (pages 1–12): Ann K. DalyChapter 2 Pharmacogenetics in Drug Metabolism: Role of Phase I Enzymes (pages 13–80): Vita DolzanChapter 3 Pharmacogenetics of Phase II Drug Metabolizing Enzymes (pages 81–100): Ingolf CascorbiChapter 4 Pharmacogenetics of Drug Transporters (pages 101–148): Henriette E. Meyer zu Schwabedissen, Markus Grube and Heyo K. KroemerChapter 5 Pharmacogenetics of Drug Targets (pages 149–182): Ann K. Daly and Maria ArranzChapter 6 Cardiovascular Pharmacogenetics (pages 183–213): Bas J. M. Peters, Anthonius de Boer, Tom Schalekamp, Olaf H. Klungel and Anke?Hilse Maitland?van der ZeeChapter 7 Pharmacogenetics in Psychiatry (pages 215–250): Evangelia M. Tsapakis, Sarah Curran, Ruth I. Ohlsen, Nora S. Vyas, Katherine J. Aitchison and Ann K. DalyChapter 8 Pharmacogenetics in Cancer (pages 251–270): Sharon MarshChapter 9 Pharmacogenetics of Asthma and COPD (pages 271–294): Ellen S. Koster, Jan A. M. Raaijmakers, Anke?Hilse Maitland?van der Zee and Gerard H. KoppelmanChapter 10 Pharmacogenetics of Adverse Drug Reactions (pages 295–321): Ann K. Daly, Martin Armstrong and Munir PirmohamedChapter 11 Pharmacogenomics of Inflammatory Bowel Diseases (pages 323–351): Alexander Teml, Susanne Karner, Elke Schaeffeler and Matthias SchwabChapter 12 Pharmacogenetics of Pain Medication (pages 353–374): Jorn LotschChapter 13 Ethical and Social Issues in Pharmacogenomics Testing (pages 375–400): Susanne Vijverberg, Toine Pieters and Martina CornelChapter 14 High?Throughput Genotyping Technologies for Pharmacogenetics (pages 401–414): Beatriz Sobrino and Angel CarracedoChapter 15 Developments in Analyses in Pharmacogenetic Datasets (pages 415–435): Alison A. Motsinger?ReifChapter 16 Applications of Pharmacogenetics in Pharmaceutical Research and Development (pages 437–460): Daniel K. Burns and Scott S. SundsethChapter 17 Role of Pharmacogenetics in Registration Processes (pages 461–475): Myong?Jin Kim, Issam Zineh, Shiew?Mei Huang and Lawrence J. LeskoChapter 18 Pharmacogenetics: Possibilities and Pitfalls (pages 477–483): Anke?hilse Maitland?van der Zee and Ann K. Daly

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