ENGLISH

2-Oxoglutarate-Dependent Oxygenases

By Peter Hedden , Janet Smith , Robert Hausinger , Christopher Schofield , C David Garner , J. Martin Bollinger , Johanna Myllyharju , Ray Trievel , Tina Muller , Pål Falnes , L Aravind , Robert Sabbatini , Frederic Vaz , Ronald Wanders , Stefan Martens , Inger Andersson , Peter Rutledge , Graham Moran , Larry Que , Robert P Hausinger , Jalila Simaan , Chuan He

Book information

Publisher
Royal Society of Chemistry
Year
2015
ISBN
1849739501, 9781849739504
Language
english
Format
PDF
Filesize
15 MB (15761346 bytes)
Series
RSC Metallobiology 3
Pages
480\506
Time added
2015-05-04 19:44:10

Description

Since the discovery of the first examples of 2-oxoglutarate-dependent oxygenase-catalysed reactions in the 1960s, a remarkably broad diversity of alternate reactions and substrates has been revealed, and extensive advances have been achieved in our understanding of the structures and catalytic mechanisms. These enzymes are important agrochemical targets and are being pursued as therapeutic targets for a wide range of diseases including cancer and anemia.This book provides a central source of information that summarizes the key features of the essential group of 2-oxoglutarate-dependent dioxygenases and related enzymes. Given the numerous recent advances and biomedical interest in the field, this book aims to unite the latest research for those already working in the field as well as to provide an introduction for those newly approaching the topic, and for those interested in translating the basic science into medicinal and agricultural benefits.The book begins with four broad chapters that highlight critical aspects, including an overview of possible catalytic reactions, structures and mechanisms. The following seventeen chapters focus on carefully selected topics, each written by leading experts in the area. Readers will find explanations of rapidly evolving research, from the chemistry of isopenicillin N synthase to the oxidation mechanism of 5-methylcytosine in DNA by ten-eleven-translocase oxygenases.

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