ENGLISH

Aldo-Keto Reductases and Toxicant Metabolism

By Trevor M. Penning and J. Mark Petrash (Eds.)

Book information

Publisher
American Chemical Society
Year
2003
ISBN
9780841238466, 9780841219700, 0-8412-3846-4
DOI
10.1021/bk-2003-0865
ISSN
0097-6156
Language
english
Format
PDF
Filesize
25 MB (26139460 bytes)
Series
ACS Symposium Series 865
Pages
250\250
Time added
2013-09-09 05:00:00

Description

Content: SECTION 1: GENERAL OVERVIEW ; 1. Introduction and Overview of the Aldo-Keto Reductase (AKR) Superfamily ; SECTION 2: AKRS AND ENDOGENOUS TOXICANTS ; 2. Aldo-Keto Reductase-Catalyzed Detoxication of Endogenous Aldehydes Associated With Diabetic Complications ; 3. Aldose Reductase Detoxifies Lipid Aldehydes and Their Glutathione Conjugates ; 4. Role of Aldose Reductase in the Detoxification of Oxidized Phospholipids ; SECTION 3: AKRS AND EXOGENOUS TOXICANTS: TOBACCO RELATED CARCINOGENS ; 5. Competing Roles of Reductases in the Detoxification of the Tobacco-Specific Nitrosamine Ketone NNK ; 6. Aldo-Keto Reductases and the Metabolic Activation of Polycyclic Aromatic Hydrocarbons ; 7. Molecular Cloning and Characterization of Dihydrodiol Dehydrogenase from Mouse ; 8 Efficient Synthesis of the Active Metabolites of Carcinogenic Polycyclic Aromatic Hydrocarbons ; 9. Chemistry of PAH o-Quinones Generated by the AKR Pathway of PAH Activation ; 10. Analysis of Etheno-2'-Deoxyguanosine Adducts as Dosimeters of AKR Mediated Oxidative Stress ; SECTION 4: AKRS AND EXOGENOUS TOXICANTS: MYCOTOXINS, ALDEHYDES AND KETONES ; 11. Aflatoxin Aldehyde Reductases ; 12. Competing Reactions of Aflatoxin B1-Dialdehyde: Enzymatic Reduction vs Adduction with Lysine ; 13. The use of mammalian cell lines to investigate the role of aldo-keto reductases in the detoxication of aldehydes and ketones ; SECTION 5: AKRS, THE STRESS RESPONSE AND CELL SIGNALING ; 14. Aldose Reductase and the Stress Response ; 15. Aldose Reductase Regulates Reactive Oxygen Species Mediated-Inflammatory Signals ; 16. Aldo-Keto Reductases in the Stress Response of the Budding Yeast Saccharomyces cerevisiae

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