Supercritical Fluid Chromatography: Volume 1

Description

Supercritical Fluid Chromatography (SFC) provides a timely overview of SFC application areas which were unimaginable just a decade ago. This two-volume series opens with an overview of the history and expectant future of SFC and continues with recent applications in the pharmaceutical industry and other fascinating areas of science. SFC has found its place in the pharmaceutical industry with an increasing body of applications for chiral and achiral molecules in both the research and development phases of the drug discovery process. As illustrated in this two-volume series, the current interest in SFC extends well beyond the pharmaceutical industry. Chapters encompassing applications for polar and non-polar mixtures of importance are covering widely disparate areas in substance abuse, natural products including cannabinoids, bioactive lipids, flavor and fragrance. With its broad balance and coverage, this two-volume book constitutes a unique educational platform to students and scientists for many years to come. The major objective of this book editions is to inspire and stimulate readers to continue exploring the possibilities of exploiting supercritical fluids as a particular media for analysis, purifications and synthesis An extensive overview of this modern technique which became indispensable in pharmaceutical industry. Bridges the gap between theory and real practical use. Written by practicing chromatographers. Contains numerous figures and examples. Preface Contents List of Contributors 1. A history of supercritical fluid chromatography (SFC) 2. Achiral preparative supercritical fluid chromatography 3. Addressing robust operation and reproducibility in SFC 4. SFC within early drug discovery research – a user’s perspective 5. What is the potential of SFC-MS for doping control analysis? 6. SFC as a novel approach to assess polarity and identify intramolecular hydrogen bonding 7. Applications of supercritical fluid chromatography: Natural products in pharmaceutical, cosmetic, and food applications 8. Analytical chiral supercritical fluid chromatography Index