ENGLISH

Resistance of Cancer Cells to CTL-Mediated Immunotherapy

By Benjamin Bonavida , Salem Chouaib (eds.)

Book information

Publisher
Springer International Publishing
Year
2015
ISBN
978-3-319-17806-6, 978-3-319-17807-3
DOI
10.1007/978-3-319-17807-3
Language
english
Format
PDF
Filesize
7 MB (7018835 bytes)
Series
Resistance to Targeted Anti-Cancer Therapeutics 7
Edition
1
Pages
353\358
Time added
2015-07-18 18:00:00
Cancer Research; Drug Resistance; Molecular Medici

Description

This comprehensive volume explores the latest research on the mechanisms of resistance in cancer cells to CTL-mediated immunotherapy. Chapter topics discuss cell-mediated immunity as the result of cytotoxic T-lymphocytes (CTL) directed specifically against cancer cells. In addition, the volume reviews how CTL mediate the cytotoxic activity, in large part, by the indication of apoptosis; hence, tumor cells develop anti-apoptotic mechanisms and thereby, resist CTL-induced apoptosis. In order for CTL-mediated antitumor immunotherapy to be effective, it is essential that agents directed against the resistant tumor cells sensitized cancer cells for CTL-mediated apoptosis. Examples of such agents discussed in the volume include are HDAC inhibitors, proteasome inhibitors, Bcl-2 family inhibitors, PARP, antibodies, and more.

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