Alzheimer’s Disease Theranostics

Description

Alzheimer’s Disease Theranostics discusses the latest information on recent theranostic avenues for both the diagnosis and treatment of Alzheimer’s patients. It presents the pros and cons of the probable mechanistic role of nanoparticles in crossing the blood-brain barrier and improving disease symptoms. Finally, it highlights the merits of existing maneuvers and suggests perspectives to aid in future developments. Despite the difficulty of drug delivery to the brain, there are some nanoparticulate platforms demonstrating promise in treating neurodegenerative disorders such as Alzheimer’s disease. Manifold theranostic maneuvers include antioxidants, natural bioactive compounds, gene therapy, and nanotechnological approaches, all of which are discussed in this important work. Examines various theranostic applications for the diagnosis and treatment of Alzheimer’s diseaseFeatures a comprehensive overview of nanoparticle therapeutics in the area and use of antioxidantsAssesses the common challenges and lessons learned from blood-brain barrier challenges, viral vector approaches and mitochondria-targeted therapeutics Cover Alzheimer’s Disease Theranostics Copyright Dedication Biography Acknowledgements 1 - Introduction: Alzheimer’s Disease Pathology and Therapeutics Abstract Keywords Introduction Biochemistry Theranostics Antibodies Natural Compounds Resveratrol Ginkgo Biloba Drugs Nanotechnology Conclusion and Future Perspectives REFERENCES 2 - Early Diagnosis of Alzheimer’s Disease Abstract Keywords Introduction Curcumin Creative Drawing Technique Imaging Techniques Positron Emission Tomography Radiotracers Genetics Biomarkers Blood Biomarkers Protein Biomarkers miRNA Glucose Levels Conclusion REFERENCES 3 - Antioxidants in Alzheimer’s Therapy Abstract Keywords Introduction Antioxidants Plant Extracts Withanolides Neuroinflammation-Targeted Therapeutics Antioxidant Enzymes Limitations Melatonin Lipoic Acid Nanotechnology Conclusion REFERENCES 4 - Natural Products in the Treatment of Alzheimer’s Disease Abstract Keywords Introduction Flavonoids Epigallocatechin-3-Gallate Resveratrol Saikosaponins Curcumin Click Chemistry Nanotechnology Chitosan Conclusion REFERENCES 5 - Blood-Brain Barrier–Targeted Nanotechnological Advances Abstract Keywords Introduction Physiology Pathology BCSFB Therapeutics Matrix Metalloproteinases Nanoparticles Gold nanoparticles Liposomes Magnetic nanoparticles Conclusions and Future Perspectives REFERENCES 6 - Gene Therapy: The Cornerstone in the Development of Alzheimer’s Disease Therapeutics Abstract Keywords Introduction Presenilin Stem Cells MicroRNA/CDK5R1 Heat Shock Protein Beclin Apolipoprotein E Drug Mechanism/Gene Modification Neuroinflammation and Cytokines Conclusion REFERENCES 7 - Viral Vector Therapeutics Against Alzheimer’s Disease Abstract Keywords Introduction Viral Vector Therapeutics Adeno-Associated Viral Vectors mAbs Tau Progranulin Neprilysin Gene-Based Immunotherapeutic Methods Conclusion REFERENCES 8 - Mitochondria-Targeted Nanoparticles: A Milestone or a Mirage in the Treatment of Alzheimer’s Disease Abstract Keywords Introduction Nanoparticles Flurbiprofen Nanoparticles Nattokinase Nanoparticles Intranasal Delivery Triphenylphosphonium Functionalization Cerium Oxide Nanoparticles Conclusion REFERENCES 9 - Nanoparticles: The Double-Edged Swords Abstract Keywords Introduction Nanotechnology Polymeric Materials Carbon Nanotubes Hydrogels Tissue Engineering Scaffolds Delivery Systems for Growth Factors Delivery Systems for Chelators Demerits of Biomaterials Conclusions and Future Perspectives REFERENCES 10 - Alzheimer Therapeutics: Pros and Cons Abstract Keywords Introduction Neuroinflammation and Cytokines Demerits Antioxidants Shortcomings Drug Mechanism/Gene Modification Neprilysin Limitations Nanotechnology Gold Nanoparticles Liposomes Magnetic Nanoparticles Cerium Oxide Nanoparticles Limitations of Mitochondria-Targeted Therapeutics Demerits of Biomaterials Conclusions and Future Perspectives REFERENCES Index A B C D E F G H I L M N O P Q R S T V W