Imaging and metabolism

Description

This book presents advanced molecular imaging techniques used to assess metabolic function. Covering state-of-the art modalities, it discusses the evaluation of a wide range of diseases that have a metabolic component, including cancer, inflammatory conditions, diabetes, neurodegeneration, and cardiovascular disorders. Imaging provides a quantitative perspective to the assessment of metabolic function and complements genetic analysis of disorders related to disrupted metabolism. Organized into four parts, the book highlights basic principles in molecular imaging techniques; metabolic imaging approaches, including magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and hybrid modalities; metabolic diseases; and future perspectives. Featuring contributions from leading authorities in radiology, oncology, cardiology, and neurology, Imaging and Metabolism is a pioneering exploration of the role of imaging modalities in assessing the physiological status of abnormal cells and diagnosing disease. Front Matter ....Pages i-xiii Front Matter ....Pages 1-1 Molecular Imaging and Molecular Imaging Technologies (Katja Haedicke, Susanne Kossatz, Thomas Reiner, Jan Grimm)....Pages 3-27 A Topical Report on the Design Principles of Metabolism (Christopher J. Halbrook, Ho-Joon Lee, Lewis C. Cantley, Costas A. Lyssiotis)....Pages 29-44 Front Matter ....Pages 45-45 Overview of Positron-Emission Tomography Tracers for Metabolic Imaging (Ephraim Parent, Jonathan McConathy)....Pages 47-80 Introduction: MRI/MRS as Metabolic Imaging Tools (David Wilson, Michael Ohliger)....Pages 81-98 Metabolic Imaging Approaches: Optical Imaging (Matthew A. Wall, Tiffany M. Heaster, Karissa Tilbury, Woo June Choi, Darren Roblyer, Ruikang Wang et al.)....Pages 99-126 Front Matter ....Pages 127-127 Cancer Metabolism (Daniel R. Wahl, Sriram Venneti)....Pages 129-154 Inflammation and Immune Metabolism (Carmen Paus, Derk Draper, Mangala Srinivas, Erik H. J. G. Aarntzen)....Pages 155-173 Imaging in Diabetes (Liang Zhang, Greg M. Thurber)....Pages 175-197 Brain Disorders (Vesselin Z. Miloushev, Ronald G. Blasberg)....Pages 199-222 Fatty Liver Disease (Scott C. Beeman, Joel R. Garbow)....Pages 223-241 Imaging Myocardial Metabolism (Robert J. Gropler, Craig R. Malloy)....Pages 243-279 Other Metabolic Syndromes (Matthew T. Whitehead, Andrea L. Gropman)....Pages 281-324 Back Matter ....Pages 325-331