Drug Adherence in Hypertension and Cardiovascular Protection

Description

This book provides a critical and comprehensive review of the methodologies available for measuring drug adherence in clinical practice, including those relying on emerging technologies. The authors discuss the risk factors of non-adherence and shed light on how to identify patients at risk of poor adherence. Drug therapies in chronic diseases rely heavily on the patient's adherence, since drugs that are not taken are ineffective and leave the patient at high risk of developing clinical complications. Given the absence of new drugs for the treatment of hypertension, drug adherence is particularly important in these patients to improve blood pressure control. The book further investigates a new aspect, namely the importance of drug adherence in clinical trials and studies and draws attention to the limits of developing drugs without significant information on drug adherence. Several chapters are dedicated to the importance of adherence in specific forms of hypertension, such as resistant hypertension, dyslipidemia and hypertension associated with cardiovascular risk. As experts confronted with drug adherence in their daily practice, the authors analyse the real effectiveness of several interventions aimed at improving drug adherence and put particular emphasis on the importance of an interdisciplinary approach involving nurses and pharmacists. The volume also includes a careful analysis of the health and economic impact of poor adherence. The book is aimed at physicians, pharmacists, students and all health professionals dealing not only with hypertension or dyslipidemia, but also with chronic asymptomatic diseases such as diabetes, HIV or chronic respiratory diseases. Front Matter ....Pages i-viii Taxonomy of Medication Adherence: Recent Developments (Michel Burnier, Bernard Vrijens)....Pages 1-8 Front Matter ....Pages 9-9 Qualitative Assessments of Adherence (Michel Burnier, Grégoire Wuerzner)....Pages 11-19 Electronic Monitoring of Medication Adherence: From Dose-Counting to Dose-Clocking (Bernard Vrijens, Eric Tousset)....Pages 21-27 Measurements of Antihypertensive Medications in Blood and Urine (Pankaj Gupta, Prashanth Patel, Maciej Tomaszewski)....Pages 29-41 Adherence to Antihypertensive and Cardiovascular Preventive Treatment: The Contribution of the Lombardy Database (Giuseppe Mancia, Federico Rea, Giovanni Corrao)....Pages 43-56 Directly Observed Therapy in Hypertension (DOT-HTN) (Ulla Hjørnholm, Mikaela Aamodt, Anne Cecilie Larstorp, Fadl Elmula M. Fadl Elmula, Aud Høieggen, Marit Helen Andersen et al.)....Pages 57-85 Digital Medicines to Measure Drug Ingestion Adherence (Naunihal S. Virdi)....Pages 87-97 Ethical Aspects of Measuring Adherence to Antihypertensive Treatment (Paul Hjemdahl)....Pages 99-104 Front Matter ....Pages 105-105 Determinants and Barriers to Adherence in Hypertension (Valentina Forni Ogna, Michel Burnier)....Pages 107-122 Beliefs and Adherence in Hypertension and Cardiovascular Protection (Amy Chan, Rob Horne)....Pages 123-141 Front Matter ....Pages 143-143 Impact of Drug Adherence in Clinical Trials (Michel Burnier)....Pages 145-151 The Impact of Antihypertensive Drugs on Adherence (Ian M. Kronish, Nathalie Moise)....Pages 153-172 Medication Persistence in Hypertension in General Practice (Miriam Qvarnström, Björn Wettermark, Thomas Kahan)....Pages 173-184 Drug Adherence in Resistant Hypertension (Idir Hamdidouche, Vincent Jullien, Stéphane Laurent, Michel Azizi)....Pages 185-197 Drug Adherence with Cardiovascular Medicines: Statins and Aspirin (Maarit Jaana Korhonen, Emma Aarnio)....Pages 199-217 Which Interventions Are Useful? (Todd Ruppar)....Pages 219-223 Use of Fixed-Dose Combinations in Hypertension and Cardiovascular Disease Prevention (Massimo Volpe, Giuliano Tocci, Giovanna Gallo)....Pages 225-235 Nurse Led Interventions in Hypertension (Christopher E. Clark)....Pages 237-252 Role of the Pharmacist in Supporting Adherence (Marie P. Schneider, Parisa Aslani)....Pages 253-269 Integrated Approaches to Support Medication Adherence: The Case of Hypertension (Valérie Santschi)....Pages 271-281 Use of Apps to Improve Drug Adherence in Hypertensive Patients (Parati Gianfranco, Pellegrini Dario, Torlasco Camilla)....Pages 283-293 Front Matter ....Pages 295-295 Global Clinical Consequences of Poor Adherence (Sylvie Perreault)....Pages 297-314