Personalized Therapy for Multiple Myeloma

Description

This book provides the clinician with concise, practical guidance on risk stratification and therapeutic decision making in patients with multiple myeloma. In addition, the available clinical trial and research data are summarized into meaningful reviews and evidence-based recommendations for treatment are presented. The coverage encompasses all phases and forms of disease, including high-risk myeloma. Over recent decades, greater understanding of the biology of myeloma has fostered the development of new, more effective drugs, leading to remarkable improvements in survival. To continue this momentum, several recent prospective trials have aimed to identify further potential therapeutic targets or to evaluate various combinations of anti-myeloma agents. The increasing abundance of management options makes the decision making complex in different phases of the disease. This book will offer the clinician valuable assistance in the choice and sequencing of therapies, highlighting the need for a personalized approach that reflects the growing recognition that myeloma is not one uniform disease. Front Matter ....Pages i-ix Risk Stratification in Newly Diagnosed Smoldering Multiple Myeloma (María-Victoria Mateos, Jesús San-Miguel)....Pages 1-13 Risk Stratification in Newly Diagnosed Transplant-Eligible Multiple Myeloma (Megan H. Jagosky, Alankrita Taneja, Manisha Bhutani)....Pages 15-36 Risk Stratification in Newly Diagnosed Transplant Ineligible Multiple Myeloma (Massimo Offidani, Laura Corvatta, Silvia Gentili, Elena Aghemo, Antonio Palumbo, Laura Maracci et al.)....Pages 37-58 Treatment of t(4;14) and del(17p) in Multiple Myeloma (Pieter Sonneveld)....Pages 59-76 Treatment of Patients in First or Second Relapse (Andrew J. Yee, Noopur S. Raje)....Pages 77-102 Treatment of Patients in Third Relapse and Beyond Including Double-Refractory Disease (Douglas Tremblay, Siyang Leng, Ajai Chari)....Pages 103-120 Plasma Cell Leukemia (Nisha S. Joseph, Amarendra K. Neppalli, Ajay K. Nooka)....Pages 121-129 Practical Considerations for Bone Health in Multiple Myeloma (Evangelos Terpos, Nikolaos Kanellias)....Pages 131-167 Personalizing MM Treatment: Gaps in Current Knowledge (Shaji Kumar)....Pages 169-178