Cannabis Use Disorders

Description

This book is an unbiased scientific compendium documenting the state-of-the-art in the etiology, diagnosis and treatment of Cannabis Use Disorders (CUD). Unlike any other current medical text, this volume focuses on the scientific aspects of CUDs and provides a resource for researchers, physicians and other health care providers who treat patients suffering from the disorder or its consequences. It begins by establishing the landscape of the disorder, including its prevalence, association with disabilities and comorbidities, and frequency of patients seeking treatment. The text delves into the complexity of the disorder in today’s environment by including the discoveries on the nature and extent of the endocannabinoid system as well as potential breakthroughs in safe and effective pharmacological and nonpharmacological treatments. Experts in the field contribute discussions on the most cutting-edge diagnostic and biological topics, including genetics, medical consequences, and clinical manifestations. The text also covers the challenges and risks presented by external factors, including social repercussions, protective factors, psychiatric comorbidities, withdrawal, and treatment services. Cannabis Use Disorders is a vital resource for researchers, psychiatrists, psychologists, addiction medicine specialists, toxicologists, hospital administrators, nurses, social workers, and all health care professionals working with patients who misuse cannabis. Front Matter ....Pages i-xii Introduction to Cannabis Use Disorders (Ivan D. Montoya, Susan R. B. Weiss)....Pages 1-6 Epidemiology of Cannabis Use Disorder (Marsha Lopez, Carlos Blanco)....Pages 7-12 Genetic Aspects of Cannabis Use Disorder (Lisa Blecha, Geneviève Lafaye, Amine Benyamina)....Pages 13-20 The Endogenous Cannabinoid System: A Cadre of Potential Therapeutic Targets (Steven G. Kinsey, Aron H. Lichtman)....Pages 21-29 Cannabidiol and Cannabis Use Disorder (María S. García-Gutiérrez, Francisco Navarrete, Adrián Viudez-Martínez, Ani Gasparyan, Esther Caparrós, Jorge Manzanares)....Pages 31-42 The Molecular Basis of Cannabinoid Activity: Application to Therapeutics Design and Discovery for Cannabis Use Disorders (David R. Janero, V. Kiran Vemuri, Alexandros Makriyannis)....Pages 43-54 Translation of CUD Therapeutics from Drug Discovery to the Clinic (Aidan J. Hampson, Robert L. Walsh)....Pages 55-62 Animal Models of Cannabis Use Disorder (Zuzana Justinova)....Pages 63-74 Human Laboratory Models of Cannabis Use Disorder (Caroline A. Arout, Evan Herrmann, Margaret Haney)....Pages 75-84 Clinical Manifestations of Cannabis Use Disorder (Alan J. Budney, Jacob T. Borodovsky, Ashley A. Knapp)....Pages 85-91 Cannabis Withdrawal (Nicolas J. Schlienz, Ryan Vandrey)....Pages 93-102 Cannabis and Cannabinoid Intoxication and Toxicity (Ziva D. Cooper, Arthur Robin Williams)....Pages 103-111 Psychiatric Comorbidity of Cannabis Use Disorder (David A. Gorelick)....Pages 113-125 The Association Between Cannabinoids and Psychosis (Sai Krishna Tikka, Deepak Cyril D’Souza)....Pages 127-155 Medical Consequences of Cannabis Use (Jag H. Khalsa, Ruben Baler)....Pages 157-167 Synthetic Cannabinoid Use (Laurent Karila, Amine Benyamina)....Pages 169-176 Cannabis Use Disorder During the Perinatal Period (Martha L. Velez, Chloe J. Jordan, Lauren M. Jansson)....Pages 177-188 Cannabis Use Disorder as a Developmental Disorder (Rachel L. Tomko, Amber N. Williamson, Aimee L. McRae-Clark, Kevin M. Gray)....Pages 189-199 Cannabinoids to Treat Cannabis Use Disorders (Christina A. Brezing, Frances R. Levin)....Pages 201-205 Neurotransmitter and Neuropeptide Targets for Cannabis Use Disorder Treatment (Brian J. Sherman, Aimee L. McRae-Clark)....Pages 207-211 Anticonvulsants to Treat Cannabis Use Disorder (Barbara J. Mason)....Pages 213-220 Prodrugs as Treatments for Cannabis Use Disorder: N-Acetylcysteine as a Case Example (Kevin M. Gray)....Pages 221-227 Non-pharmacological Treatments for Cannabis Use Disorders (Will M. Aklin, Michele Bedard-Gilligan)....Pages 229-236 Mindfulness-Based Practices for the Treatment of Cannabis Use Disorder (David Shurtleff)....Pages 237-243 Cannabis Use Disorder Treatment and Reimbursement (Andrew M. Kiselica, Amy Duhig)....Pages 245-252 International Aspects of CUD (Steven W. Gust, Graciela Ahumada, Jan Copeland, Paul Griffiths, John Howard, Marya Hynes)....Pages 253-263 Back Matter ....Pages 265-271