Heart Failure: Bench to Bedside

Description

Heart Failure (HF) is the final and common pathway of all cardiovascular diseases. Heart Failure: Bench to Bedside helps address a significant need to develop new paradigms and to identify novel therapeutic targets for this pervasive disease. An authoritative contribution to the field, this book provides a detailed description of new findings and emerging methodologies, as well as a critical clinical evaluation of the complex HF syndrome and future therapies. Heart Failure: Bench to Bedside includes a primer on gene profiling and bioenergetics of the normal heart and a discussion of the molecular, genetic, biochemical and cellular techniques critical to understanding HF. Further chapters discuss cardiac remodeling, oxidative stress, and alterations in other organs and systems that are often associated with HF. Heart Failure: Bench to Bedside thoughtfully evaluates current and forthcoming diagnostic techniques and therapies, pharmaceutical and pharmacogenomic-based individualized medicine, gene and cell-based therapies, and the search for new frontiers. Heart Failure: Bench to Bedside presents a clear view of up-to-date approaches to clinical diagnosis and treatment, as well as offering insightful critiques of original and creative scientific thoughts on post-genomic HF research. Front Matter....Pages i-xi Front Matter....Pages 1-1 Introduction to Heart Failure....Pages 3-13 Cardiac Function in Heart Failure: The Role of Calcium Cycling....Pages 15-21 Gene Profiling of the Failing Heart: Epigenetics....Pages 23-42 Front Matter....Pages 44-44 Bioenergetics and Metabolic Changes in the Failing Heart....Pages 45-69 Front Matter....Pages 72-72 The Multidimensional Role of Mitochondria in Heart Failure....Pages 73-106 Front Matter....Pages 108-108 Animal Models of Heart Failure....Pages 109-127 Front Matter....Pages 130-130 Signaling Cascades in Heart Failure: From Cardiomyocytes Growth and Survival to Mitochondrial Signaling Pathways....Pages 131-160 Cyclic Nucleotides Signaling (Second Messengers) and Control of Myocardial Function: Effects of Heart Failure....Pages 161-169 Calcium Signaling: Receptors, Effectors, and Other Signaling Pathways....Pages 171-194 Oxidative Stress and Heart Failure....Pages 195-211 Cardiac Remodeling and Cell Death in Heart Failure....Pages 213-231 Front Matter....Pages 234-234 Heart Failure and Changes at the Periphery: Vascular, Inflammation, Neurohormonal, and Renal Systems....Pages 235-255 Comorbidities in Heart Failure....Pages 257-270 Front Matter....Pages 272-272 Mechanisms and Clinical Recognition and Management of Heart Failure in Infants and Children....Pages 273-295 Mechanical Circulatory Support and Heart Transplantation in Children with Severe Refractory Heart Failure....Pages 297-312 Front Matter....Pages 314-314 Basic Mechanisms Mediating Cardiomyopathy and Heart Failure in Aging....Pages 315-340 Heart Failure of Aging: Clinical Considerations....Pages 341-349 Front Matter....Pages 352-352 Diagnosis of Heart Failure: Evidence-Based Perspective....Pages 353-363 “Omics” Application in Heart Failure: Novel Diagnostic and Prognostic Markers to Understand Pathophysiology and Find New Therapies....Pages 365-376 Front Matter....Pages 378-378 Treatment of Chronic Heart Failure....Pages 379-392 Front Matter....Pages 378-378 Gene Therapy in Heart Failure: Forthcoming Therapies....Pages 393-408 Myocardial Cell-Based Regeneration in Heart Failure....Pages 409-427 Front Matter....Pages 430-430 Future Frontiers in Heart Failure....Pages 431-446 Back Matter....Pages 447-470