ENGLISH

Metabolism of Drugs and Other Xenobiotics

Book information

Year
2012
ISBN
9783527329038, 9783527630905
DOI
10.1002/9783527630905
Language
english
Format
PDF
Filesize
5 MB (5056471 bytes)
Pages
743\743
Orientation
yes
Scanned
yes
Time added
2013-08-01 04:00:00

Description

A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and ?designer? drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.Content: Chapter 1 Drug?Metabolizing Enzymes–An Overview (pages 1–25): Pavel Anzenbacher and Eva AnzenbacherovaChapter 2 Cytochromes P450 (pages 27–66): F. Peter GuengerichChapter 3 UDP?Glucuronosyltransferases (pages 67–116): Christian P. Strassburg and Sandra KalthoffChapter 4 Sulfotransferases (pages 117–145): Michael W. H. CoughtrieChapter 5 Glutathione S?Transferases (pages 147–164): Miroslav Dostalek and Anna?Katarina StarkChapter 6 Hydrolytic Enzymes (pages 165–198): Bingfang YanChapter 7 Transporting Systems (pages 199–222): Anne T. Nies, Claudia Resch and Tadashi NamisakiChapter 8 Transcriptional Regulation of Human Drug?Metabolizing Cytochrome P450 Enzymes (pages 223–258): Zdenek DvorakChapter 9 Importance of Pharmacogenomics (pages 259–284): Prof. Dr. Ulrich M. Zanger, Kathrin Klein and Jessica RiegerChapter 10 Introduction to Drug Metabolism (pages 285–300): Prof. Dr. Ulrich M. ZangerChapter 11 Central Nervous System Drugs (pages 301–329): Pierre Baumann and Christoph HiemkeChapter 12 Cardiovascular Drugs (pages 331–363): Stephan Riedmaier and Prof. Dr. Ulrich M. ZangerChapter 13 Anticancer Drugs (pages 365–378): Matthias Schwab, Elke Schaeffeler and Hiltrud BrauchChapter 14 Antimicrobial Agents (pages 379–402): Chantal Csajka, Oscar Marchetti, Oriol Manuel, Laurent Decosterd and Amalio TelentiChapter 15 Drugs against Acute and Chronic Pain (pages 403–428): Andrew A. Somogyi and Janet K. CollerChapter 16 Drugs of Abuse (Including Designer Drugs) (pages 429–463): Markus R. Meyer and Hans H. MaurerChapter 17 Nicotine Metabolism and its Implications (pages 465–492): Andy Z. X. Zhu and Rachel F. TyndaleChapter 18 Metabolism of Alcohol and its Consequences (pages 493–516): Helmut K. Seitz and Sebastian MuellerChapter 19 Introduction and Overview (pages 517–542): Michael MurrayChapter 20 Flavonoids (pages 543–582): Petr HodekChapter 21 St John's Wort (Hypericum Perforatum L.) (pages 583–610): Miroslav Dostalek and Anna?Katarina StarkChapter 22 Food Components and Supplements (pages 611–635): Alexandr ParlesakChapter 23 Environmental Pollutants (pages 637–670): Marie StiborovaChapter 24 Environmental Estrogens (pages 671–684): Miroslav Machala and Jan VondracekChapter 25 Biotransformation of Insecticides (pages 685–702): Corie A. Ellison, Alice L. Crane and James R. Olson

Similar books

Session C11: Ancient Cultural Landscapes in South Europe – their Ecological Setting and Evolution, Session C22: Gardeners from South America, Session S04: Agro-Pastoralism and Early Metallurgy Sessions, Session WS29: The Idea of Enclosure in Recent Iberian Prehistory, Session C88: Rhytmes et causalites des dynamiques de l'anthropisation en Europe entre 6500 ET 500 BC: Hypotheses socio-culturelles et/ou climatiques: Proceedings of the XV UISPP World Congress (Lisbon 4-9 September 2006) / Actes du XV Congrès Mondial (Lisbonne 4-9 Septembre 2006) Vol.36

Session C11: Ancient Cultural Landscapes in South Europe – their Ecological Setting and Evolution, Session C22: Gardeners from South America, Session S04: Agro-Pastoralism and Early Metallurgy Sessions, Session WS29: The Idea of Enclosure in Recent Iberian Prehistory, Session C88: Rhytmes et causalites des dynamiques de l'anthropisation en Europe entre 6500 ET 500 BC: Hypotheses socio-culturelles et/ou climatiques: Proceedings of the XV UISPP World Congress (Lisbon 4-9 September 2006) / Actes du XV Congrès Mondial (Lisbonne 4-9 Septembre 2006) Vol.36

2010 · PDF

THE BRITISH ARMY IN INDIA: ITS PRESERVATION BY AN APPROPRIATE CLOTHING, HOUSING, LOCATING, RECREATIVE EMPLOYMENT, AND HOPEFUL ENCOURAGEMENT OF THE TROOPS. with AN APPENDIX ON INDIA : THE CLIMATE OP ITS HILLS ; THE DEVELOPMENT OF ITS RESODRCBS, INDUSTRY, AND ARTS ; THE ADMINISTRATION OF JUSTICE ; THE BLACK ACT ; THE PROGRESS OF CHRISTIANITY ; THE TRAFFIC IN OPIUM ; THE VALUE OF INDIA ; PERMANENT CAUSES OF DISAFFECTION, AND OF THE RECENT REBELLION ; THE TRADITIONARY POLICY; MISGOVERNMENT BY NATIVE RULERS ; ANNEXATIONS OF THEIR TERRITORY, ETC.

THE BRITISH ARMY IN INDIA: ITS PRESERVATION BY AN APPROPRIATE CLOTHING, HOUSING, LOCATING, RECREATIVE EMPLOYMENT, AND HOPEFUL ENCOURAGEMENT OF THE TROOPS. with AN APPENDIX ON INDIA : THE CLIMATE OP ITS HILLS ; THE DEVELOPMENT OF ITS RESODRCBS, INDUSTRY, AND ARTS ; THE ADMINISTRATION OF JUSTICE ; THE BLACK ACT ; THE PROGRESS OF CHRISTIANITY ; THE TRAFFIC IN OPIUM ; THE VALUE OF INDIA ; PERMANENT CAUSES OF DISAFFECTION, AND OF THE RECENT REBELLION ; THE TRADITIONARY POLICY; MISGOVERNMENT BY NATIVE RULERS ; ANNEXATIONS OF THEIR TERRITORY, ETC.

1858 · PDF

Idries Shah 27 Books Collection : A Perfumed Scorpion, A Veiled Gazelle, Caravan of Dreams, Darkest England, Destination Mecca, Evenings with Idries Shah, Knowing How to Know, Learning How to Learn, Letters and Lectures of Idries Shah, Neglected aspects of Sufi study, Observations, Oriental Magic, Reflections, Seeker after Truth, Special Illumination, Special Problems in the study of Sufi ideas, Sufi thought and action, Tales of the Dervishes, The Dermis Probe, The Elephant in the Dark, The Englishman Handbook, Idries Shah Antology, The Magic Monastery, The natives are restless, wisdom of the Idiots PDF.

Idries Shah 27 Books Collection : A Perfumed Scorpion, A Veiled Gazelle, Caravan of Dreams, Darkest England, Destination Mecca, Evenings with Idries Shah, Knowing How to Know, Learning How to Learn, Letters and Lectures of Idries Shah, Neglected aspects of Sufi study, Observations, Oriental Magic, Reflections, Seeker after Truth, Special Illumination, Special Problems in the study of Sufi ideas, Sufi thought and action, Tales of the Dervishes, The Dermis Probe, The Elephant in the Dark, The Englishman Handbook, Idries Shah Antology, The Magic Monastery, The natives are restless, wisdom of the Idiots PDF.

2022 · PDF

The travels of Capts. Lewis and Clarke from St. Louis, by way of the Missouri and Columbia rivers, to the Pacific ocean; performed in the years 1804, 1805 & 1806, by order of the government of the United States. Containing delineations of the manners, customs, religion, &c. of the Indians, comp. from various authentic sources, and original documents, and a summary of the Statistical view of the Indian nations, from the official communication of Meriwether Lewis. Illustrated with a map of the country, inhabited by the western tribes of Indians

The travels of Capts. Lewis and Clarke from St. Louis, by way of the Missouri and Columbia rivers, to the Pacific ocean; performed in the years 1804, 1805 & 1806, by order of the government of the United States. Containing delineations of the manners, customs, religion, &c. of the Indians, comp. from various authentic sources, and original documents, and a summary of the Statistical view of the Indian nations, from the official communication of Meriwether Lewis. Illustrated with a map of the country, inhabited by the western tribes of Indians

1809 · PDF

Professional Linux kernel architecture ''Wrox programmer to programmer''--Cover. - ''What you are reading right now is the result of an evolution over more than seven years: After two years of writing, the first edition was published in German by Carl Hanser Verlag in 2003. It then described kernel 2.6.0. The test was used as a basis for the low-level design documentation for the EAL4+ security evaluation of Red Hat Enterprise Linux 5, requiring to update it to kernel 2.6.18 (if the EAL acronym does not mean anything to you, then Wikipedia is once more your friend). Hewlett-Packard sponsored the translation into English and has, thankfully, granted the rights to publish the result. Updates to kernel 2.6.24 were then performed specifically for this book''--P. ix

Professional Linux kernel architecture ''Wrox programmer to programmer''--Cover. - ''What you are reading right now is the result of an evolution over more than seven years: After two years of writing, the first edition was published in German by Carl Hanser Verlag in 2003. It then described kernel 2.6.0. The test was used as a basis for the low-level design documentation for the EAL4+ security evaluation of Red Hat Enterprise Linux 5, requiring to update it to kernel 2.6.18 (if the EAL acronym does not mean anything to you, then Wikipedia is once more your friend). Hewlett-Packard sponsored the translation into English and has, thankfully, granted the rights to publish the result. Updates to kernel 2.6.24 were then performed specifically for this book''--P. ix

2008 · PDF