Inhibitors of Monoamine Oxidase B: Pharmacology and Clinical Use in Neurodegenerative Disorders

Description

Front Matter ....Pages i-xviii Front Matter ....Pages 1-1 Anatomy of the Human Basal Ganglia (H. Braak, E. Braak)....Pages 3-23 The Pathophysiological Basis of Parkinson’s Disease (M. Gerlach, P. Riederer)....Pages 25-50 Parkinson’s Disease and Its Existing Therapy (P.-A. Fischer)....Pages 51-71 Front Matter ....Pages 73-73 Medicinal Chemistry of Present and Future MAO-B Inhibitors (J. Gaál, I. Hermecz)....Pages 75-108 l-Deprenyl: A Unique MAO-B Inhibitor (E. E. Polymeropoulos)....Pages 109-124 Pharmacology of Monoamine Oxidase Type B Inhibitors (K. Magyar)....Pages 125-143 The Pharmacological Basis of the Therapeutic Effect of (—)-Deprenyl in Age-Related Neurological Diseases (J. Knoll)....Pages 145-168 Neurotoxins and Monoamine Oxidase B Inhibitors: Possible Mechanisms for the Neuroprotective Effect of (—)-Deprenyl (V. Glover, M. Sandler)....Pages 169-181 The Mode of Action of MAO-B Inhibitors (M. Gerlach, P. Riederer, M. B. H. Youdim)....Pages 183-200 Pharmacokinetics and Clinical Pharmacology of Selegiline (E. H. Heinonen, M. I. Anttila, R. A. S. Lammintausta)....Pages 201-213 Preclinical Evaluation of l-Deprenyl: Lack of Amphetamine-Like Abuse Potential (S. Yasar, G. Winger, B. Nickel, G. Schulze, S. R. Goldberg)....Pages 215-233 Front Matter ....Pages 235-235 The History of l-Deprenyl (M. J. Parnham)....Pages 237-251 MAO-B Inhibitors in Neurological Disorders with Special Reference to Selegiline (K. Wessel)....Pages 253-275 (—)-Deprenyl Combined with L-Dopa in the Treatment of Parkinson’s Disease (T. S. Elizan)....Pages 277-288 Neuroprotective Effects of MAO-B Inhibition: Clinical Studies in Parkinson’s Disease (P. A. LeWitt)....Pages 289-299 Alzheimer’s Disease and l-Deprenyl: Rationales and Findings (P. N. Tariot, L. S. Schneider, S. V. Patel, B. Goldstein)....Pages 301-317 Do MAO-B Inhibitors Have Any Role in the Treatment of Depression? (G. Laux)....Pages 319-326 The Therapeutic Place and Value of Present and Future MAO-B Inhibitors — l-Deprenyl as the Gold Standard (P. Riederer, M. B. H. Youdim)....Pages 327-338 Back Matter ....Pages 339-367