ENGLISH

Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of α-Aryl Ketones

By Robert Doran (auth.)

Book information

Publisher
Springer International Publishing
Year
2015
ISBN
978-3-319-20543-4, 978-3-319-20544-1
DOI
10.1007/978-3-319-20544-1
Language
english
Format
PDF
Filesize
13 MB (13283328 bytes)
Series
Springer Theses
Edition
1
Pages
202\218
Time added
2015-07-18 18:00:00
Organic Chemistry; Catalysis; Medicinal Chemistry

Description

This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereo control, which is significant because it allows the configuration of a new stereo centre to be controlled by a simple change of proton source.

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