ENGLISH

Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases

By Richard K. Burt (Editor) , Dominique Farge (editor) , Milton A. Ruiz (editor) , Riccardo Saccardi (editor) , John A. Snowden (editor)

Book information

Publisher
CRC Press
Year
2021
ISBN
1138558559, 9781138558557
Language
english
Format
PDF
Filesize
39 MB (40752867 bytes)
Edition
1
Pages
666\687
Time added
2021-10-03 18:35:27

Description

This book summarizes the progress made across the international medical and scientific research communities towards the goal of converting a chronic autoimmune disease into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies to generate sustained immune tolerance. This book succinctly covers the entire field of hematopoietic stem cell therapy for the treatment of autoimmune diseases. Utilizing the authors' extensive experience, this title provides advice on best practice and evaluates the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, it provides the ideal guide to HSCT for all conditions, from multiple sclerosis (MS) to diabetes, and provides general guidance on the transplantation process. Key Features Outlines therapies and techniques for HSCT for autoimmune diseases, and d Discusses its the advantages of HSCT over conventional therapies Reviews the entire process of stem cell therapy from harvest and ethics to indications of efficacy. Cover Half Title Title Page Copyright Page CONTENTS Foreword Preface Acknowledgments About the Editors List of Contributors SECTION I: BIOLOGY OF IMMUNE CELLS 1. B Cells in Aging, Age-Associated Diseases and Stem Cell Transplantation 2. T Cell Biology: Changes with Disease, Aging, and Hematopoietic Stem Cell Transplantation 3. Plasma Cells in Autoimmunity 4. Car T Cells for Autoimmunity 5. Regulatory T Cells for the Treatment of Autoimmune Diseases 6. Mesenchymal Stromal Cell-Derived Extracellular Vesicles SECTION II: BIOLOGY OF STEM CELLS 7. Induced Pluripotent Stem Cells: The Story of Genetic Reprogramming 8. Mesenchymal Stromal Cell Biology and Clinical Application 9. Neural Stem Cell Biology 10. Hematopoietic Stem Cells: Hierarchical versus Continuum 11. Biology of Umbilical Cord Blood Cells SECTION III: REGULATORY REQUIREMENTS 12. Quality, Accreditation, and Regulation in Hematopoietic Stem Cell Transplantation 13. European Perspective on Cellular Therapy: Good Tissue Practice (GTP) versus Good Manufacturing Practice (GMP) 14. GMP Facility Requirements in the United States SECTION IV: MESENCHYMAL STEM CELLS FOR IMMUNE DISEASES 15. Mesenchymal Stromal Cell Therapy for Acute Graft versus Host Disease—From Bench to Clinical Approval 16. Adipose-Derived Stem Cells for Systemic Sclerosis Digital Ulcers 17. Musculoskeletal Stromal/Progenitor Cell-Based Cell Therapy for Rheumatoid Arthritis (RA): MSC for Cell Therapy in RA 18. Mesenchymal Stromal Cells for Systemic Sclerosis 19. Mesenchymal Stem Cells (MSC) for Systemic Lupus Erythematosus (SLE) 20. Mesenchymal Stem/Stromal Cells for Multiple Sclerosis and Other Neurological Diseases 21. Mesenchymal Stromal Cells for Perianal Fistulizing Crohn’s Disease 22. Umbilical Cord Blood or Mesenchymal Stromal Cells as Potential Therapies for Autism Spectrum Disorder SECTION V: GENERAL CONCEPTS—HSCT FOR AUTOIMMUNE DISEASES 23. Animal Models of Bone Marrow Transplantation for Autoimmune Diseases 24. Autologous HSCT Conditioning Regimens for Autoimmune Diseases 25. Immune Reconstitution after Hematopoietic Stem Cell Transplantation in Autoimmune Disease 26. Microbiota and Immune Response 27. Infectious Complications in Patients Undergoing HSCT for Autoimmune Diseases 28. Early Toxicity and Supportive Care of HSCT for Autoimmune Diseases 29. Late Toxicity and Supportive Care of Patients Undergoing Hematopoietic Cell Transplantation for Autoimmune Diseases 30. Transfusion Medicine 31. International Registries Sites/Indications/Activity for HSCT in Autoimmune Diseases: The European Society for Blood and Marrow Transplantation (EBMT) and Center for International Blood and Marrow Transplant Research (CIBMTR) 32. Hematopoietic Stem Cell Mobilization, Collection, Apheresis, and Harvest Procedures SECTION VI: ALLOGENEIC HSCT FOR AUTOIMMUNE DISEASE 33. Hematopoietic Stem Cell Donor Registries: Search Strategies and HLA Methodologies 34. Allogeneic HSCT and Graft versus Host Disease (GvHD): General Principles with Reference to Autoimmune Diseases 35. Hematopoietic Cell Transplantation in Monogenic Autoimmune Diseases 36. Advances in the Pathogenesis and Treatment of Immune-Mediated Aplastic Anemia SECTION VII: HSCT FOR AUTOIMMUNE DISEASE 37. Magnetic Resonance Imaging in Multiple Sclerosis 38. Multiple Sclerosis 39. Disease-Modifying Therapies and Supportive Care of Multiple Sclerosis 40. Autologous Hematopoietic Stem Cell Transplantation for Secondary Progressive Multiple Sclerosis 41. Autologous Hematopoietic Stem Cell Transplantation for Relapsing-Remitting Multiple Sclerosis 42. Immune Mechanisms of Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis 43. Chronic Inflammatory Demyelinating Polyradiculoneuropathy: Basics and Interpretation of Electrodiagnostic Testing 44. Diagnosis and Differentiation of CIDP from Other Peripheral Polyneuropathies 45. Hematopoietic Stem Cell Transplantation for Chronic Inflammatory Demyelinating Polyradiculoneuropathy 46. Neuromyelitis Optica: Autologous and Allogeneic HSCT for AQP4-IgG-Positive Neuromyelitis Optica Spectrum Disorders 47. Systemic Sclerosis 48. The Systemic Sclerosis Heart 49. Scleroderma Renal Crisis with Special Considerations for Autologous Hematopoietic Stem Cell Transplant 50. Systemic Sclerosis and the Lung 51. Autologous Hematopoietic Stem Cell Transplantation in Systemic Sclerosis 52. Crohn’s Disease: Incidence, Diagnosis, Standard Treatment, Prognosis, Outcome Measures 53. Hematopoietic Stem Cell Transplantation an Alternative to Treat Crohn’s Disease 54. Type 1 Diabetes Mellitus: Hematopoietic Stem Cell Transplantation for Type 1 Diabetes Mellitus 55. Systemic Lupus Erythematosus: Hematopoietic Stem Cell Transplantation for Systemic Lupus Erythematosus (SLE) SECTION VIII: HSCT FOR AUTOIMMUNE DISEASE—DEVELOPING INDICATIONS 56. Refractory Celiac Disease: Hematopoietic Stem Cell Transplantation for Refractory Celiac Disease Type II 57. Hematopoietic Stem Cell Transplantation for Juvenile Idiopathic Arthritis 58. Hematopoietic Stem Cell Transplantation for Rheumatoid Arthritis 59. Hematopoietic Stem Cell Transplantation for Behçet’s Syndrome 60. Hematopoietic Stem Cell Transplantation and Myasthenia Gravis 61. Autologous Hematopoietic Stem Cell Transplantation in Stiff Person Spectrum Disorder 62. Hematopoietic Stem Cell Transplant-Based Treatment for Psychiatric Disorders 63. Hematopoietic Stem Cell Transplantation for Psoriasis and Pemphigus Vulgaris SECTION IX: ETHICS AND ECONOMICS 64. Health Economics of Autoimmune Diseases Using Multiple Sclerosis as a Model 65. Is Health Care a Human Right? 66. Ethics of Stem Cells and Stem Cell Transplantation for Autoimmune Diseases Appendices Index

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