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453427b......Page 1 453430f......Page 3 453432a......Page 5 453434a......Page 7 453435b......Page 8 453437a......Page 9 453438a......Page 10 453439a......Page 11 453441e......Page 12 453442a......Page 13 453446a......Page 16 453449c......Page 19 453451a......Page 21 453453a......Page 23 453455a......Page 25 453456a......Page 26 453459a......Page 28 453461a......Page 30 453463a......Page 32 453465a......Page 35 453467a......Page 36 Abstract......Page 37 Figure 1 Discovery image and X-ray light curve of XRO 080109/SN 2008D.......Page 38 Figure 3 Optical and ultraviolet light curves of XRO 080109/SN 2008D, and model fit.......Page 39 The properties of the fast ejecta......Page 40 Figure 5 Volumetric rate of X-ray outbursts similar to XRO 080109.......Page 41 References......Page 42 Low-dimensional keratocyte shape space......Page 43 Figure 2 Quantitative and correlative analysis of keratocyte morphology and speed.......Page 44 Figure 3 A quantitative model explains the main features of keratocyte shapes.......Page 45 Figure 4 An extended model predicts lamellipodial curvature and the relationship between speed and morphology.......Page 46 References......Page 47 Methods References......Page 49 Rpn13 docks ubiquitin conjugates at the proteasome......Page 50 Figure 1 Murine Rpn13 binds ubiquitin chains.......Page 51 Figure 3 Rpn13 uses loops to bind ubiquitin.......Page 52 Figure 4 Rpn13 binds to ubiquitin and UBLs of proteasomal receptors.......Page 53 Figure 6 Phenotypic effects of the loss of ubiquitin receptor function by Rpn13.......Page 55 References......Page 56 Figure 5 An Rpn13 mutant specifically defective in ubiquitin chain binding.......Page 54 Overall structure of the RecA-ssDNA filament......Page 58 Figure 1 Structure of the presynaptic nucleoprotein filament.......Page 59 Figure 3 The non-hydrolysable ATP analogue ADP-AlF4 binds at a RecA-RecA interface.......Page 60 Figure 4 Structure of the postsynaptic nucleoprotein filament.......Page 61 Figure 5 Complementary-strand binding.......Page 62 References......Page 63 Structure determination and refinement......Page 64 Methods References......Page 65 Figure 1 Random walk trajectories.......Page 66 References......Page 69 Figure 3 Spatial dependence of the transmission on the output surface.......Page 67 Figure 5 Le´vy walk in an inhomogeneous medium.......Page 68 Abstract......Page 70 Figure 4 Spinodal decomposition in samples that form gels.......Page 73 References......Page 74 Methods References......Page 75 Figure 1 Composition and structure of experimental gel and fluid samples.......Page 71 Figure 3 Comparison of n(s) mapping of experimental cp to kBT/U.......Page 72 Figure 1 The D17O of evaporite and barite sulphate over the past 750 million years.......Page 76 References......Page 78 Figure 3 Model-calculated partial pressures of CO2 based on the lowest sulphate D17O value for a given period in geological history.......Page 77 Abstract......Page 79 Figure 4 Application of the FFM to a Colima lava.......Page 81 Figure 2 Acoustic-emission energy release rates for Colima and Bezymianny lavas at different strain rates.......Page 80 Table 1 Summary of experimental conditions......Page 83 Figure 3 Schematic diagrams comparing faulting in silicic magma to tectonic faulting and showing where fault zones may develop during a lava dome eruption.......Page 85 Figure 2 Experimental results from high-temperature fracture of Mt Shasta andesite.......Page 84 Diagnosis......Page 87 References......Page 90 Figure 2 Gerobatrachus hottoni, gen. et sp. nov., holotype specimen USNM 489135.......Page 88 Figure 4 Majority rule consensus tree of 131 most parsimonious trees.......Page 89 Abstract......Page 91 Figure 4 CHIR99021 acts via inhibition of GSK3 to enhance ES-cell growth capacity and viability.......Page 94 Methods References......Page 96 Figure 2 Effects of 3i components on intracellular signalling cascades.......Page 92 Figure 3 ES-cell propagation in 3i does not involve STAT3.......Page 93 Figure 1 Specification of the cardiac lineage from human ESCs.......Page 97 References......Page 101 Methods References......Page 102 Figure 2 Identification and characterization of the cardiovascular KDRlow/C-KITneg embryoid body population.......Page 98 Figure 3 Characterization of the KDRlow/C-KITneg-derived lineages.......Page 99 Figure 4 Identification and characterization of human cardiovascular progenitors.......Page 100 Figure 1 VEC-Cre-mediated Pten loss leads to MPD and leukaemogenesis.......Page 103 References......Page 106 Methods References......Page 108 Figure 3 b-Catenin activation in LSCs and its role in leukaemogenesis.......Page 104 Figure 4 The recurring translocation T(14;15) involves the Tcra/Tcrd cluster and the c-myc gene and results in aberrant overexpression of c-myc in LSCs and T-ALL blasts.......Page 105 Abstract......Page 109 Figure 3 Endo-siRNAs have a role in gene regulation.......Page 112 Methods References......Page 114 Figure 1 Both piRNA and siRNA systems control transposons in mouse oocytes.......Page 110 Figure 2 Gene-pseudogene interactions produce endogenous siRNAs.......Page 111 Abstract......Page 115 Figure 4 Structure of the trans-nat-siRNA cluster pair at the loci of Ppp4r1 and its processed pseudogene.......Page 118 Methods References......Page 120 Figure 2 Structure of the hp-siRNA cluster at the Au76 locus.......Page 116 Figure 3 Structure of the cis-nat-siRNA cluster at the Pdzd11/Kif4 locus.......Page 117 Figure 1 Robust clonal heterogeneity.......Page 121 References......Page 124 Methods References......Page 125 Figure 2 Restoration of heterogeneity from sorted cell fractions.......Page 122 Figure 4 Clonal heterogeneity of Sca-1 expression reflects transcriptome-wide noise.......Page 123 Figure 1 Crystal structure of mRpn13 Pru reveals typical pleckstrin-homology fold.......Page 126 References......Page 130 Figure 2 Structure of Rpn13 Pru-ubiquitin complex defines a novel ubiquitin-binding motif.......Page 127 Figure 3 Preferential binding to the proximal subunit of K48-linked diubiquitin by Rpn13 Pru allows Uch37 access to the distal subunit.......Page 128 Figure 4 Structural comparison of ubiquitin receptors complexed with ubiquitin.......Page 129 Abstract......Page 131 Figure 3 Transport of radiolabelled ATP by E. coli cells expressing E. cuniculi transporters.......Page 133 References......Page 134 Methods References......Page 135 Figure 2 Evidence that E. cuniculi EcNTT3 is targeted to mitosomes.......Page 132 nj7194-557a......Page 136 nj7194-558a......Page 137 nj7194-560c......Page 139 nj0211......Page 140 nj0212......Page 141 453562a......Page 142