ENGLISH

Oncogenes Meet Metabolism: From Deregulated Genes to a Broader Understanding of Tumour Physiology (Ernst Schering Foundation Symposium Proceedings 07.4)

By Guido Kroemer , Dominik Mumberg , Hector Keun , Björn Riefke , Thomas Steger-Hartmann , Kirstin Petersen

Book information

Publisher
Springer
Year
2008
ISBN
9783540794776, 9783540794783, 3540794778
Open Library ID
OL22981302M
Language
english
Format
PDF
Filesize
4 MB (4075993 bytes)
Edition
1
Pages
275\275
Time added
2011-08-31 04:54:40

Description

In 1920s, Otto Warburg described the phenomenon of ‘aerobic glycolysis’, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg’s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).

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