Treatment Resistance in Psychiatry: Risk Factors, Biology, and Management

Description

This book reviews all the important aspects of treatment-resistant psychiatric disorders, covering issues such as definitions, clinical aspects, neurobiological correlates, treatment options, and predictors of treatment response. The book is divided into three sections, the first of which examines the most recent thinking on treatment resistance in psychiatry, including definition and epidemiology, paradigm shift in the study of the subjects, individual susceptibility and resilience, abnormal structural or functional connectivity, and insights from animal models. The second section then discusses treatment resistance in each of the major psychiatric disorders, with particular focus on the responsible clinical and biological factors and the available management strategies. Finally, more detailed information is presented on diverse pharmacological and non-pharmacological therapeutic interventions. The book, written by leading experts from across the world, will be of value to all who seek a better understanding of the clinical-neurobiological underpinnings and the development of management for treatment resistance in psychiatric disorders. Front Matter ....Pages i-xv Front Matter ....Pages 1-1 Definition and Epidemiology of Treatment Resistance in Psychiatry (Sanne Y. Smith-Apeldoorn, Jolien K. E. Veraart, Robert A. Schoevers)....Pages 3-24 Paradigm Shift in Study of Treatment-Resistant Psychiatric Disorder (Sang Won Jeon, Meysam Amidfar, Yong-Ku Kim)....Pages 25-31 Genetic Factors Underlying Treatment Resistance in Psychiatry (Eduard Maron, Chen-Chia Lan, David Nutt)....Pages 33-63 Using Neuroimaging and Electroencephalography for Prediction of Treatment Resistance in Psychiatric Disorders (Je-Yeon Yun, Seung-Hwan Lee)....Pages 65-77 Developing Therapies for Treatment-Resistant Depressive Disorder in Animal Models (Michel Bourin)....Pages 79-86 Integrated Approaches for Treatment-Resistant Psychiatric Disorders (Seon-Cheol Park, Yong-Ku Kim)....Pages 87-96 Front Matter ....Pages 97-97 Treatment-Resistant Depression: Understandings on the Neurobiological Etiology that Lead to Novel Pharmacological Treatment Options (Eunsoo Won, Byoung-Joo Ham, Yong-Ku Kim)....Pages 99-107 Treatment-Resistant Schizophrenia: Assessment and Management (Sandeep Grover, Harsh Garekar, Anisha Agarwal)....Pages 109-137 Treatment Resistance in Bipolar Disorders (Marsal Sanches, João Quevedo, Jair C. Soares)....Pages 139-150 Treatment Resistance in Post-traumatic Stress Disorder (Alexander Cowell McFarlane)....Pages 151-164 Treatment Resistance in Obsessive-Compulsive Disorder (Rachel Middleton, Michael G. Wheaton, Reilly Kayser, H. Blair Simpson)....Pages 165-177 Treatment of Opioid Dependence (Michael Soyka)....Pages 179-187 Treatment-Resistant Panic Disorder (Mu-Hong Chen, Shih-Jen Tsai)....Pages 189-206 Treatment Resistance in Anxiety Disorder: Generalized Anxiety Disorder and Social Anxiety Disorder (Kang Soo Lee, Sang Hyuk Lee)....Pages 207-214 Treatment Resistance in Attention-Deficit/Hyperactivity Disorder (Amber D. Hunt, David W. Dunn, Hillary S. Blake, Jennifer Downs)....Pages 215-235 Treatment Resistance in Tourette Syndrome (Renata Rizzo, Mariangela Gulisano)....Pages 237-252 Treatment-Resistant Eating Disorders (Youl-Ri Kim, Jione Kim)....Pages 253-260 Comorbid Sleep and Wake Problems in Treatment-Resistant Psychiatric Conditions (Seung-Gul Kang, Heon-Jeong Lee, Yong-Ku Kim, Leen Kim)....Pages 261-270 Front Matter ....Pages 271-271 Creative, Person-Centered Psychopharmacology for Treatment Resistance in Psychiatry (Miro Jakovljevic)....Pages 273-293 A Psychodynamic Approach to Treatment Resistance (Elizabeth Weinberg, Erin Seery, Eric M. Plakun)....Pages 295-310 Cognitive Behavioral Therapy and Behavioral Activation Therapy for Treatment-Resistant Depression: Traditional and Digital Therapy Perspectives (Jennifer Apolinário-Hagen, Lara Fritsche, Liesemarie Albers, Christel Salewski)....Pages 311-323 Novel Neurostimulation Therapeutic Approaches for Treatment-Resistant Psychiatric Disorders (Ralph J. Koek, Janine Roach, Nicholas Athanasiou, Arkady Korotinsky)....Pages 325-347 When Clozapine Fails: Augmentation Strategies in the Management of Clozapine-Resistant Schizophrenia (Domenico De Berardis, Michele Fornaro, Annalisa Anastasia, Federica Vellante, Alessandro Valchera, Marilde Cavuto et al.)....Pages 349-367 Fecal Microbiota Transplantation in the Treatment-Resistant Psychiatric Disorders (Alper Evrensel, Mehmet Emin Ceylan)....Pages 369-376 Neurosurgical Intervention for Treatment-Resistant Psychiatric Disorders (Daniel E. Nijensohn, Teodoro Forcht Dagi)....Pages 377-403 Back Matter ....Pages 405-416