Precision molecular pathology of myeloid neoplasms

Description

This volume provides a comprehensive, state-of-the art review of myeloid neoplasms. The book presents updated information on epidemiology, clinical presentation, morphologic findings, molecular genomic abnormalities, pathogenesis, and target therapies. The text helps to guide accurate diagnosis, the administration of appropriate ancillary molecular tests, patient management, and investigative efforts. The book also includes over 200 illustrations, photographs, and tables. Written by experts in the field, Precision Molecular Pathology of Myeloid Neoplasms serves as a valuable resource for pathologists, hematologists/oncologists, fellows, and researchers in understanding the molecular pathology of myeloid neoplasms. Front Matter ....Pages i-xi Acute Myeloid Leukemia with Recurrent Genetic Abnormalities: Part I Cytogenetic Abnormalities (Jenny Hoffmann, Dahui Qin)....Pages 1-25 Acute Myeloid Leukemia with Recurrent Genetic Abnormalities, Part II: Mutations Involving CEBPA, NPM1, and RUNX1 (Ryan S. Robetorye)....Pages 27-46 Acute Myeloid Leukemia with Myelodysplasia-Related Changes, Therapy-Related Myeloid Neoplasms, and Acute Myeloid Leukemia, Not Otherwise Specified (Peng Li, Robert S. Ohgami)....Pages 47-82 Myelodysplastic Syndrome (Shaoying Li, C. Cameron Yin)....Pages 83-98 Chronic Myeloid Leukemia, BCR-ABL1 Positive (Ren Ching Wang, Chung-Che (Jeff) Chang)....Pages 99-113 Updates in Polycythemia Vera (Vidya Nagrale, Randall Olsen, Youli Zu)....Pages 115-139 Essential Thrombocythemia (April A. Ewton, Rachel E. Donohue)....Pages 141-154 Primary Myelofibrosis (Chunyan Liu, Suyang Hao)....Pages 155-179 Mastocytosis (David Czuchlewski, Tracy I. George)....Pages 181-198 Chronic Myeloproliferative Neoplasm, Rare Types (Jerald Z. Gong, Guldeep K. Uppal)....Pages 199-211 Atypical Chronic Myeloid Leukemia, BCR/ABL1 Negative (Katherine Boothe Levinson, Adam Bagg)....Pages 213-232 Chronic Myelomonocytic Leukemia: Clinical and Pathologic Features (Michael Gentry, Eric D. Hsi)....Pages 233-247 Juvenile Myelomonocytic Leukemia (Joanna Wiszniewska, Choladda V. Curry)....Pages 249-260 Down Syndrome-Associated Hematologic Disorders and Leukemia (Amy M. Coffey, Brian Y. Merritt, Choladda V. Curry)....Pages 261-280 Inherited and Acquired Myeloid Neoplasms of Childhood (Kevin E. Fisher, M. Monica Gramatges)....Pages 281-310 Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of PDGFRA, PDGFRB, FGFR1, or t(8;9)(p22;p24.1);PCM1-JAK2 (Joanna M. Chaffin, Natasha M. Savage)....Pages 311-341 Mixed Phenotype Acute Leukemia (Olga K. Weinberg)....Pages 343-351 Blastic Plasmacytoid Dendritic Cell Neoplasm (Michael J. Cascio, Robert S. Ohgami)....Pages 353-367 Existing and Emerging Molecular Technologies in Myeloid Neoplasms (Eric Q. Konnick, David Wu)....Pages 369-412 Back Matter ....Pages 413-427