Lipoprotein Subfractions Omega-3 Fatty Acids

Description

On November 6 and 7, 1987, lipid and lipoprotein researchers from all over Europe convened in Munich on the occasion of the second European Workshop on Lipid Metabolism (EWLM). This informal gathering was devoted to two main topics, and recent research results were presented and discussed during a poster session. Recent developments in the physiology and pathophysiology of lipoprotein sub­ fractions were discussed on the first day of the meeting. In recent years, new analytical tools have been created for analyzing lipoprotein subfractions, particularly the apolipoprotein component. With the, introduction of immunological and elec­ trophoretic methods it has become clear that the heterogeneity of the plasma lipopro­ tein system is even greater than had been assumed only a decade or so ago. Despite this, it is apparent from the contributions to this volume that new methods for differentiating lipoprotein subfractions will increase our understanding of lipoprotein metabolism, especially of the triglyceride-rich lipoprotein particles and the high­ density lipoproteins. The complex functions of the various plasma apolipoproteins and their association with the lipoprotein lipid in single or complex lipoprotein particles give rise to a complex and dynamic metabolic system that changes constantly during the day. While it has for some time been possible to delineate fairly accurately the atherogenic potential of low-density lipoproteins, which are comparatively simple lipoprotein particles, the new methods of lipoprotein subfraction analysis will be needed to select and differentiate amongst the potentially atherogenic triglyceride­ rich particles, especially the chylomicron and very low density lipoprotein remnants. Front Matter....Pages I-XII Front Matter....Pages 1-1 The Lipoprotein Family Concept: An Update....Pages 3-11 Ultracentrifugal, Chromatographic and Electrophoretic Techniques for Lipoprotein Subfractionation....Pages 12-18 Analysis of Lipoprotein Particles Using Immunoaffinity Chromatography and ELISA Techniques....Pages 19-24 Lipoprotein Association and Function of Apolipoprotein A-IV....Pages 25-33 LP-X and Other Abnormal Lipoprotein Particles in Secondary Dyslipoproteinemia....Pages 34-37 Turnover Studies of Apolipoproteins C: A First Critical Appraisal....Pages 38-48 Lecithin: Cholesterol Acyl Transferase, Cholesterol Ester Exchange/Transfer Protein, and Lipoprotein Particles....Pages 49-55 Role of the Liver in the Metabolism of Lipoprotein Particles....Pages 56-61 LDL Subfractions and Atherosclerosis....Pages 62-67 HDL Subclasses and Atherosclerosis....Pages 68-71 Lipoprotein Deficiency Syndromes....Pages 72-81 Significance of the Interaction Between Lipoprotein Subfractions and Macrophages for Reverse Cholesterol Transport....Pages 82-87 HDL Receptor of Cultured Adipocytes and Its Role in Reverse Cholesterol Transport....Pages 88-91 Front Matter....Pages 93-93 Effects of Polyunsaturated Fatty Acids on Biochemical and Functional Aspects of Endothelial and Blood Cells....Pages 95-99 Oxidative Metabolism of Unsaturated Fatty Acids and Free Radical Formation....Pages 100-106 Omega-3 Fatty Acids and Hemostasis....Pages 107-109 The Effects of Omega-3 Fatty Acids in Multiple Sclerosis: 2-Year-Results....Pages 110-114 Omega-3 Fatty Acids, Autoimmunity, and Diabetes....Pages 115-118 Omega-3- and Omega-6 Polyunsaturated Fatty Acids: Nutritional Needs and Dietary Recommendations....Pages 119-124 Omega-3 Fatty Acid Treatment of Hyperlipidemia: Efficacy and Mechanism of Action....Pages 125-130 Back Matter....Pages 131-133