Psychotic Disorders: Comprehensive Conceptualization and Treatments

Description

Psychotic Disorders: Comprehensive Conceptualization and Treatments emphasizes a dimensional approach to psychosis—one of the most fascinating manifestations of altered brain behavior—that cuts across a broad array of psychiatric diagnoses from schizophrenia to affective psychosis and organic disorders like epilepsy and dementias. Written by an international roster of over seventy leading experts in the field, this volume comprehensively reviews, critiques, and integrates available knowledge on the etiology, mechanisms, and treatments of psychotic disorders, and outlines ways forward in both research and clinical practice towards more objective, mechanistically-based definitions of psychotic disorders. Chapters address topics such as psychosis phenomenology, biomarkers and treatments, the overlaps and interfaces between psychiatric disorders within the psychosis dimension, and novel disease definitions. Furthermore, the volume incorporates findings on potential mechanisms, bridges between various system levels (i.e., genetic, epigenetic, molecular and cellular, brain circuit and function, psychological, social, environmental and cultural) and their interactions, as well as the potential role in causation and/or mediation in psychotic disorders. Finally, the volume outlines a broad array of treatment approaches, from the readily available (e.g., psychopharmacology, various modalities of psychotherapy) to the experimental (e.g., cognitive interventions, neuromodulation). With a concluding section of forward perspectives conjecturing future directions and related challenges, this book aspires to stimulate new knowledge, generate novel frameworks, and carry new directions forward on psychotic disorders. Contents Preface • Carol A. Tamminga, Elena I. Ivleva, Ulrich Reininghaus, and Jim van Os Contributors SECTION 1: PHENOMENOLOGICAL CHARACTERISTICS AND DIMENSIONAL CONCEPTUALIZATION OF PSYCHOSIS 1. Conceptualization of psychosis in psychiatric nosology: past, present, and the future • Matcheri S. Keshavan, John Torous, and Rajiv Tandon 2. Historical epistemology of the “unitary psychosis” • German E. Berrios and Ivana S. Marková 3. Dimensional conceptualization of psychosis • Kürşat Altınbaş, Sinan Guloksuz, and Jim van Os TRANSDIAGNOSTIC DIMENSIONS OF PSYCHOSIS 4. Applying Research Domain Criteria (RDoC) dimensions to psychosis • Sarah E. Morris, Jennifer Pacheco, and Charles A. Sanislow 5. Schizophrenia, schizoaffective disorder, bipolar disorder • Barrett Kern and Sarah K. Keedy 6. Psychotic symptoms in bipolar disorder • Marsal Sanches, Xiang-Yang Zhang, and Jair C. Soares 7. Major depressive disorder with psychotic features: confronting and resolving the dimensional challenge • John L. Waddington, Tara Kingston, Nnamdi Nkire, and Vincent Russell 8. Psychosis in personality disorders • K. Nidhi Kapil-Pair, Yulia Landa, Marie C. Hansen ,Daniel H. Vaccaro, and Marianne Goodman 9. Symptom network models of psychosis • Adela-Maria Isvoranu, Lindy-Lou Boyette, Sinan Guloksuz, and Denny Borsboom PSYCHOSIS IN GENERAL MEDICAL CONDITIONS AND ORGANIC BRAIN DISORDERS 10. Organic psychosis: phenotypic deviants or clues to schizophrenia? • Peter Buckley and Brian Miller 11. Epilepsy and psychosis • Michael R. Trimble, Kousuke Kanemoto, and Dale C. Hesdorffer 12. Understanding sex differences in psychosis through the exploration of hormonal contributions • Leah H. Rubin SECTION 2: PSYCHOSIS COURSE AND LIFETIME MANIFESTATIONS EARLY PSYCHOSIS 13. Clinical phenomenology of the prodrome for psychosis • Albert R. Powers III, Thomas H. McGlashan, and Scott W. Woods 14. Predictors of conversion to psychosis • Rachael G. Grazioplene and Tyrone D. Cannon 15. First-episode psychosis: phenomenology, onset, course, and early intervention (OPUS) • Merete Nordentoft and Nikolai Albert 16. Evidence-based treatment and implementation for early psychosis • Sacha Zilkha, Iruma Bello, Hong Ngo, Samantha Jankowski, and Lisa Dixon PSYCHOSIS OVER LIFE SPAN AND LATE-LIFE PSYCHOSIS 17. Life span development of schizophrenia: symptoms, clinical course, and outcomes • Matti Isohanni, Jouko Miettunen, and Matti Penttilä 18. Phenomenological characteristics of psychosis of aging: psychosis and dementia interphase • Graham M. L. Eglit, Barton W. Palmer, and Dilip V. Jeste SECTION 3: NEUROBIOLOGY OF PSYCHOSIS HERITABILITY AND GENETICS 19. Genetic neuropathology revisited: gene expressionin psychosis • Samuel J. Allen, Rahul Bharadwaj, Thomas M. Hyde, and Joel E. Kleinman 20. Epigenomic regulation in psychosis • Bibi S. Kassim, Behnam Javidfar, and Schahram Akbarian 21. DNA modifications in schizophrenia • Ehsan Pishva and Bart P. F. Rutten 22. Endophenotypes: a window on the genetics of schizophrenia • David Braff COGNITIVE BIOMARKERS OF PSYCHOSIS 23. Cognitive biomarkers of psychosis • S. Kristian Hill, Richard S. E. Keefe, and John A. Sweeney 24. Social cognition in psychosis • Amy E. Pinkham and David L. Roberts 25. Self-awareness in schizophrenia: affected domains and their impact • Juliet M. Silberstein, Amy E. Pinkham, and Philip D. Harvey NEUROPHYSIOLOGIC BIOMARKERS OF PSYCHOSIS 26. Neurophysiologic biomarkers of psychosis: event-related potential biomarkers • Judith M. Ford, Holly K. Hamilton, Katiah Llerena, Brian J. Roach, and Daniel H. Mathalon 27. Oculomotor biomarkers of illness, risk, and pharmacogenetic treatment effects across the psychosis spectrum • James L. Reilly, Jennifer McDowell, Jeffrey Bishop, Andreas Sprenger, and Rebekka Lencer BRAIN IMAGING BIOMARKERS 28. Structural connectivity in psychosis • Amanda E. Lyall, Johanna Seitz, and Marek Kubicki 29. Functional connectivity biomarkers of psychosis • Godfrey Pearlson and Michael Stevens 30. MR spectroscopy • Adrienne C. Lahti and Nina V. Kraguljac PATHOPHYSIOLOGY OF PSYCHOSIS: NEUROTRANSMITTERS 31. Dopaminergic mechanisms underlying psychosis • Michael A. P. Bloomfield and Oliver D. Howes 32. Glutamate in the pathophysiology of schizophrenia • Daniel C. Javitt 33. GABAergic mechanisms in psychosis • Takanori Hashimoto and David A. Lewis 34. Alteration in nicotinic receptors in psychotic disorders: molecular neurobiology and clinical relevance • Robert Freedman 35. Muscarinic acetylcholine receptors in the etiology and treatment of schizophrenia • M. S. Moehle, S. E. Yohn, and P. J. Conn 36. Kynurenic acid in brain function and dysfunction: focus on the pathophysiology and treatment of schizophrenia • Robert Schwarcz and Sophie Erhardt PATHOPHYSIOLOGY: VOLTAGE- GATED ION CHANNELS IN PSYCHOSIS 37. Genetic association of voltage-gated ion channels with psychotic disorders • Charles H. Large 38. Voltage-gated ion channels in neural circuits implicated in psychotic disorders • Charles H. Large PATHOPHYSIOLOGY: IMMUNE MECHANISMS 39. Inflammatory mechanisms in psychosis • Anna P. McLaughlin, Carmine M. Pariante, and Valeria Mondelli 40. Autoimmune processes in mental disorders • Marina Mané-Damas, Carolin Hoffmann, Shenghua Zong, Peter C. Molenaar, Mario Losen, and Pilar Martinez- Martínez BRAIN CIRCUIT ALTERATIONS IN PSYCHOSIS 41. The circuitry of midbrain dopamine system dysregulation in schizophrenia • Felipe V. Gomes, Eric C. Zimmerman, and Anthony A. Grace 42. Feeling and remembering: effects of psychosis on the structure and function of the amygdala and hippocampus • M. D. Bauman, J. D. Ragland, and C. M. Schumann 43. The cerebellum in psychosis • Kelsey Heslin, Joseph J. Shaffer, Albert Powers, Nancy Andreasen, and Krystal Parker SECTION 4: SOCIOENVIRONMENTAL MECHANISTIC FACTORS IN PSYCHOSIS EARLY LIFE ADVERSITY 44. Perinatal factors in psychosis • Mary Clarke and Mary Cannon 45. The role of early life experience in psychosis • Richard P. Bentall 46. Socioenvironmental adversity across the life span • Peter Bosanac and David J. Castle 47. Migration, ethnicity, and psychoses • Craig Morgan PSYCHOLOGICAL MECHANISMS AND PSYCHOSIS 48. Cognitive and emotional processes in psychosis • Steffen Moritz, Thies Lüdtke, Łukasz Gawęda, Jakob Scheunemann, and Ryan P. Balzan 49. Aberrant salience attribution and psychosis • Toby T. Winton-Brown and Shitij Kapur NEURAL CORRELATES OF SOCIOENVIRONMENTAL RISK AND PSYCHOSIS 50. Neural correlates of childhood trauma • Alaptagin Khan, Kyoko Ohashi, Maria Maier, and Martin H. Teicher 51. Neural correlates of urban risk environments • Imke L. J. Lemmers-Jansen, Anne-Kathrin J. Fett, and Lydia Krabbendam 52. Neural correlates of ethnic minority position and risk for psychosis • Jean-Paul Selten, Jan Booij, Bauke Buwalda, and Andreas Meyer-Lindenberg 53. Resilience in psychosis spectrum disorder • Lotta-Katrin Pries, Sinan Guloksuz, and Bart P. F. Rutten SECTION 5: TREATMENT OF PSYCHOTIC DISORDERS PHARMACOLOGICAL TREATMENTS 54. Pharmacological approaches to treatment • Stefan Leucht, Andrea Cipriani, and Toshi A. Furukawa 55. Animal models of psychosis: approaches and validity • Daniel Scott PSYCHOLOGICAL TREATMENTS IN PSYCHOSIS 56. Psychoanalytic treatment of psychosis • Elyn R. Saks 57. Cognitive-behavioral therapy • Tania Lincoln and Alison Brabban 58. Psychoeducation as an approach to treatment of severe mental illness • Emma Sophia Kay, David E. Pollio, and Carol S. North 59. Family interventions in psychosis • Juliana Onwumere and Elizabeth Kuipers 60. Peer support for people with psychiatric illness: a comprehensive review • Chyrell D. Bellamy, Anne S. Klee, Xavier Cornejo, Kimberly Guy, Mark Costa, and Larry Davidson 61. Mindfulness and acceptance based therapies for psychosis • Louise Johns, Mark Hayward, Clara Strauss, and Eric Morris 62. Hearing voices groups • Alison Branitsky, Eleanor Longden, and Dirk Corstens 63. AVATAR therapy: a new digital therapy for auditory verbal hallucinations • Tom K. J. Craig and Mar Rus- Calafell 64. Health in a connected world • Philippe Delespaul and Catherine van Zelst COGNITIVE REMEDIATION AND OTHER APPROACHES 65. Recovery-oriented services • Mike Slade, Eleanor Longden, Julie Repper, and Samson Tse 66. Neuroscience-informed cognitive training for psychotic spectrum illnesses • Sophia Vinogradov, Rana Elmaghraby, and Laura Pientka 67. Cognitive remediation: theory, meta-analytic evidence, and practice • Til Wykes and Adam Crowther 68. Noninvasive brain stimulation techniques in psychosis • Marine Mondino, Frédéric Haesebaert, and Jérôme Brunelin EARLY INTERVENTIONS 69. Treatment approaches in the psychosis prodrome • Andrea M. Auther and Barbara A. Cornblatt 70. From early intervention in psychosis to transformation of youth mental health reform • Ashok Malla and Patrick McGorry SECTION 6: FUTURE DIRECTIONS AND OPPORTUNITIES 71. Future directions: making a start toward the primary prevention of psychosis • Robin M. Murray, Olesya Ajnakina, and Marta Di Forti 72. A glimpse forward regarding psychopathology of psychotic disorders • William T. Carpenter 73. Time for change in psychosis research • Brett A. Clementz Index