Preeclampsia

Description

This volume is an excellent guide that comprehensively illustrates hypertensive disorders of pregnancy, especially preeclampsia, in both the basic and clinical aspects. Preeclampsia is a pregnancy-specific multi-organ disorder and a leading cause of maternal and neonatal mortality. The pathophysiology of pregnancy-specific disorders was long unknown, but recently many new findings have been reported from the point of view of pathophysiology. Furthermore, this complication of pregnancy, especially preeclampsia, is a potent risk factor for chronic conditions such as cardiovascular disease, diabetes mellitus, kidney disease, and hypertension. The book is composed of seven parts including genetic background, pathology, pathophysiology, and the latest prediction and treatment of preeclampsia. Specific basic topics such as immunological maladaptation, placental adenosine signaling, and new prediction markers are also expounded by experts. Thus it benefits not only obstetricians, pediatricians, nephrologists, diabetologists, and cardiologists, but also immunologists, endocrinologists, geneticists, pathologists, biologists, and molecular biologists who are interested in the treatment of hypertension in pregnancy. Front Matter ....Pages i-viii Front Matter ....Pages 1-1 Risk Factors for Preeclampsia (Arihiro Shiozaki, Shigeru Saito)....Pages 3-25 Front Matter ....Pages 27-27 Genetic Background of Preeclampsia (Junichi Sugawara, Yuji Oe, Maiko Wagata)....Pages 29-43 Front Matter ....Pages 45-45 Trophoblast Invasion: Remodelling of Spiral Arteries and Beyond (Berthold Huppertz)....Pages 47-62 Front Matter ....Pages 63-63 Immunological Maladaptation (Shigeru Saito, Tomoko Shima, Akitoshi Nakashima)....Pages 65-84 Glucose Intolerance and Insulin Resistance: Relevance in Preeclampsia (Keizo Kanasaki)....Pages 85-98 Placental Adenosine Signaling in the Pathophysiology of Preeclampsia (Takayuki Iriyama, Yang Xia)....Pages 99-112 Obesity, Adipokines, and Lipokines (Katsuhiko Naruse)....Pages 113-124 Autophagy in Preeclampsia (Akitoshi Nakashima, Aiko Aoki, Tae Kusabiraki, Tomoko Shima, Osamu Yoshino, Shi-Bin Cheng et al.)....Pages 125-140 Animal Models in Preeclampsia (Keiichi Kumasawa)....Pages 141-155 The Differences Between Early- and Late-Onset Pre-eclampsia (Anne Cathrine Staff, Christopher W. G. Redman)....Pages 157-172 Front Matter ....Pages 173-173 sFlt-1/PLGF (Holger Stepan, Janine Hoffmann)....Pages 175-198 Ambulatory Blood Pressure Measurement and Home Blood Pressure Measurement (Hirohito Metoki)....Pages 199-208 MicroRNA (Toshihiro Takizawa, Akihide Ohkuchi, Shigeki Matsubara, Toshiyuki Takeshita, Shigeru Saito)....Pages 209-224 Front Matter ....Pages 225-225 Novel Therapies for Preeclampsia (Suzanne D. Burke, S. Ananth Karumanchi)....Pages 227-237 Pravastatin for Preeclampsia Prevention and Treatment (Guillermina Girardi)....Pages 239-251 Prevention and Treatment of Stroke and Eclampsia (Yasumasa Ohno)....Pages 253-270 Front Matter ....Pages 271-271 Cardiovascular Disease Following Hypertensive Pregnancy (Franziska Pettit, George Mangos, Mark A. Brown)....Pages 273-290