ENGLISH

Immunological Aspects of Viral Oncolysis

By Professor Jean Lindenmann M.D. , Paul A. Klein Ph.D. (auth.)

Book information

Publisher
Springer-Verlag Berlin Heidelberg
Year
1967
ISBN
978-3-642-87046-0, 978-3-642-87044-6
DOI
10.1007/978-3-642-87044-6
Language
english
Format
PDF
Filesize
3 MB (3465516 bytes)
Series
Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer 9
Edition
1
Pages
86\91
Time added
2013-12-12 02:00:00
generalMedicine/Public Health

Description

mouse tissue alloantigen detected by this procedure. An antigen of cross-reacting specificity was revealed in tissue extracts of many other animal species. We next wanted to learn more about the antigen responsible for induction of postoncolytic immunity. Extracts from virus-infected tumors were immunogenic, and both active and inactive fractions of such extracts were obtained. The growth of the virus in the tumor cells was studied with the electron microscope, in the hope that this might shed some light on the manner in which viral infection transforms a poorly immunogenic tumor into a highly immunogenic one. We consider none of the questions which our work has raised as definitely solved. In fact, we are still working on many of the aspects alluded to above. When we embarked on a study of postoncolytic immunity, we were supported in this endeavor by our lack of experience in the fields of transplantation and tumor immunology.

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