Pancreatic Cancer

Description

The field of solid tumor oncology is changing at an astonishing rate. To learn about new developments, generate fresh research perspectives, and then integrate these advancements into clinical practice is a daunting challenge confronting all who work in the oncology arena. The onset and rapid deployment of Internet capacities worldwide has created a mileau of global and instantaneous information access. The task of staying current is - coming even more challenging, and in some ways, more difficult to accomplish. Against this information pressure backdrop, how can yet more didactic material for the already overburdened oncology physician be justified? Based on the premise that we all must remain in a learning mode if we are to remain relevant, The University of Texas M. D. Anderson Annual of Solid Tumor Oncology is designed to focus on a single disease site in each volume. It is our belief that there is an information “gray zone” that lies - tween the peer reviewed (and increasingly electronically available) individual research - port and the large comprehensive multiauthored textbook. Between these two loci there - ists an information gap that will be best served by a succinct disease site-focused volume that provides an in-depth analysis of current multimodality care for a specific solid tumor system, as well as the areas of basic, translational, and clinical research that will emerge for future clinical application. Front Matter....Pages 1-1 Molecular Epidemiology....Pages 3-13 The Molecular Biology of Pancreatic Cancer....Pages 15-28 Molecular Markers as a Tool for the Early Diagnosis of Pancreatic Cancer....Pages 29-46 Cell Signaling Pathways in Pancreatic Cancer....Pages 47-61 Epithelial Stem Cells in Pancreatic Regeneration and Neoplasia....Pages 63-72 Inherited Pancreatic Cancer Syndromes....Pages 73-81 Front Matter....Pages 83-83 Pancreatic Cancer: Radiologic Staging....Pages 85-95 Endoscopic Diagnosis and Staging: Endoscopic Ultrasound, Endoscopic Retrograde Cholangiopancreatography....Pages 97-114 Laparoscopic Staging....Pages 115-121 Front Matter....Pages 123-123 Whipple Procedure: 1935 to Present....Pages 125-137 Regional Lymph Node Dissection for Pancreatic Adenocarcinoma....Pages 139-151 Pylorus Preservation versus Standard Pancreaticoduodenectomy: Oncologic Controversies....Pages 153-159 Vascular Resection and Reconstruction for Localized Pancreatic Cancer....Pages 161-169 Techniques for Biliary and Pancreatic Reconstruction After Pancreaticoduodenectomy....Pages 171-180 Transduodenal Local Resection for Periampullary Neoplasms....Pages 181-191 Distal Pancreatectomy for Pancreatic Cancer....Pages 193-200 Risks of Perioperative Mortality with Pancreaticoduodenectomy....Pages 201-211 Endoscopic Palliation for Locally Advanced and Metastatic Disease: Biliary and Duodenal Stents....Pages 213-222 Celiac Plexus Block Versus Systemic Opioid Medication in the Management of Pancreatic Cancer Pain....Pages 223-231 Front Matter....Pages 233-233 Postoperative Adjuvant Therapy: Past, Present, and Future Trial Development....Pages 235-242 Front Matter....Pages 233-233 Preoperative (Neoadjuvant) Therapy for Resectable Adenocarcinoma of the Pancreas....Pages 243-254 European Adjuvant Trials....Pages 255-267 Adjuvant Regional Infusion Therapy....Pages 269-274 Adjuvant Regional Infusion Therapy....Pages 275-279 Adjuvant Regional Infusion Therapy....Pages 280-285 Intraoperative Radiation for Pancreatic Cancer....Pages 287-293 Conformal Radiation Therapy in Pancreatic Cancer....Pages 295-300 Radiation Sensitizers, Fractionation Schedules, and Future Clinical Trials....Pages 301-310 Cytotoxic Chemotherapy for Pancreatic Cancer: Past, Present, and Future....Pages 311-320 Front Matter....Pages 321-321 Animal Models of Pancreatic Adenocarcinoma....Pages 323-330 Strategies for Gene Therapy....Pages 331-341 Photodynamic Therapy and Endoscopic Ultrasound-Guided Therapy for Pancreatic Cancer....Pages 343-346 Vaccine Therapy for Pancreatic Cancer....Pages 347-355 Antiangiogenic Strategies in Pancreatic Cancer....Pages 357-367 Role of Matrix Metalloproteinase Inhibition in the Treatment of Pancreatic Cancer....Pages 369-376 Regulation of Pancreatic Cancer Growth by Gastrointestinal Hormones: A Clinically Useful Strategy?....Pages 377-387 Farnesyltransferase Inhibitors: Biological Considerations for Future Therapeutics....Pages 389-395 Novel Therapeutic Targets for Drug Development....Pages 397-405