Oxford Textbook of Cancer Biology

Description

The study of the biology of tumours has grown to become markedly interdisciplinary, involving chemists, statisticians, epidemiologists, mathematicians, bioinformaticians, and computer scientists alongside biologists, geneticists, and clinicians. The Oxford Textbook of Cancer Biology brings together the most up-to-date developments from different branches of research into one coherent volume, providing a comprehensive and current account of this rapidly evolving field. Structured in eight sections, the book starts with a review of the development and biology of multi-cellular organisms, how they maintain a healthy homeostasis in an individual, and a description of the molecular basis of cancer development. The book then illustrates, as once cells become neoplastic, their signalling network is altered and pathological behaviour follows. It explores the changes that cancer cells can induce in nearby normal tissue, the new relationship established between them and the stroma, and the interaction between the immune system and tumour growth. The authors illustrate the contribution provided by high throughput techniques to map cancer at different levels, from genomic sequencing to cellular metabolic functions, and how information technology, with its vast amounts of data, is integrated with traditional cell biology to provide a global view of the disease. The effect of the different types of treatments on the biology of the neoplastic cells are explored to understand on the one side, why some treatments succeed, and on the other, how they can affect the biology of resistant and recurrent disease. The book concludes by summarizing what we know to date about cancer, and in what direction our understanding of cancer is moving. Edited by leading authorities in the field with an international team of contributors, this book is an essential resource for scholars and professionals working in the wide variety of sub-disciplines that make up today's cancer research and treatment community. It is written not only for consultation, but also for easy cover-to-cover reading. Preface Acknowledgements Contents Abbreviations Contributors Section I: The multicellular organism 1. The multicellular organism and cancer • Francesco Pezzella, David J. Kerr, and Mahvash Tavassoli 2. DNA repair and genome integrity • Giacomo Buscemi 3. Evolution and cancer • Tom Donnem, Kingsley Micklem, and Francesco Pezzella Section II: The aetiology of cancer 4. Genetics and genetic instability in cancer • Mark A. Glaire and David N. Church 5. Epigenetics • Edward Hookway, Nicholas Athanasou, and Udo Oppermann 6. Viral carcinogenesis—an overview • Dirk P. Dittmer and Blossom Damania 7. Chemical carcinogens • David H. Phillips 8. Radiation as a carcinogen • Yan-Qun Xiang and Chao-Nan Qian Section III: How the cancer cell works 9. Growth factors and associated signalling pathways in tumour progression and in cancer treatment • Nadège Gaborit and Yosef Yarden 10. Hormones and cancer • Balkees Abderrahman and V. Craig Jordan 11. Oncogenesis and tumour suppression • Mahvash Tavassoli and Francesco Pezzella 12. The signalling pathways in cancer • Jiangting Hu and Francesco Pezzella 13. Cell cycle control • Simon Carr and Nicholas La Thangue 14. Cancer and cell death • Jessica Bullenkamp and Mahvash Tavassoli 15. Telomerase and immortalization • Laura Collopy and Kazunori Tomita 16. Cancer metabolism • Almut Schulze, Karim Bensaad, and Adrian L. Harris 17. Chaperones and protein quality control in the neoplastic process • Andrea Rasola 18. Oxygen and cancer: The response to hypoxia • Adrian L. Harris and Margaret Ashcroft 19. Invasion, metastasis, and tumour dormancy • Andrey Ugolkov and Andrew P. Mazar 20. Cancer stem cells • Connor Sweeney, Lynn Quek, Betty Gration, and Paresh Vyas Section IV: Cancer microenvironment 21. Cancer- associated stroma • Wilma Mesker and Rob Tollenaar 22. Blood vessels and cancer • Francesco Pezzella and Robert Kerbel 23. Cancer immunology • Herman Waldmann Section V: Global vision of cancer 24. Molecular profiling in cancer research and personalized medicine • Pieter-Jan van Dam and Steven Van Laere 25. Proteomics and metabolomics applications in cancer biology • Pedro Cutillas and Benedikt M. Kessler 26. Cancer systems biology: From molecular profiles to pathways, signalling networks, and therapeutic vulnerabilities • Lieven Verbeke and Steven Van Laere 27. Cancer biology through immunohistology • Karen Pulford and Kevin Gatter Section VI: The biology of cancer treatment 28. Principles of chemotherapy • David J. Kerr, Daniel Haller, and Jaap Verweij 29. Immunotherapy and tumour resistance to immune-mediated control and elimination • Gwennaëlle C. Monnot and Pedro Romero 30. Biological effect of radiotherapy on cancer cells • Anna Dubrovska, Mechthild Krause, and Michael Baumann Section VII: Conclusions 31. Benign tumours: The forgotten neoplasms • Francesco Pezzella, Adrian L. Harris, and Mahvash Tavassoli 32. Conclusions: Cancer biology, a moveable feast • David J. Kerr, Francesco Pezzella, and Mahvash Tavassoli Index